2002 Fiscal Year Final Research Report Summary
The Withdrawal of Immunosuppressive Regimen by CD15s monitoring
| Project/Area Number |
13671258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ISHIDA Hideki Tokyo Women's Medical University, instructor, 医学部, 助手 (60246543)
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| Co-Investigator(Kenkyū-buntansha) |
TOMA Hiroshi Tokyo Women's Medical University, Professor, 医学部, 教授 (90075549)
TOKUMOTO Tadahiko Tokyo Women's Medical University, Associate Prof, 医学部, 助手 (30246540)
TANABE Kazunari Tokyo Women's Medical University, Associate Prof, 医学部, 講師 (80188359)
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| Project Period (FY) |
2001 – 2002
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| Keywords | CD15s / Immunosuppressive Regimen / Rejection / withdrawal |
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| Research Abstract |
In ABO incompatible renal transplantation, we experienced hyper acute rejection leading to graft loss. During this period, we observed the rapid elevation of CD15s Antigen with two high peaks. Double color flow cytometric analysis demonstrated that this high peak was activated plasma cells stained by CD10Ab. No performance of splenectomy was believed to activate memory B lymphocytes in recipient's spleen. We obtained the similar result in animal experiments. High expression of CD15s was observed with senu creatinine elevation after withdrawal of Immunosuppression.
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