2003 Fiscal Year Final Research Report Summary
Studies on the predictive indexes of postoperative clinical courses and the role of the pancreatic hormones to liver regeneration after simultaneus resection of the liver and the pancreas
| Project/Area Number |
13671334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIDA Muneki Kitasato Univ. School of Medicine, Dept. of Surgery, Assistant Professor, 医学部, 講師 (50201017)
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| Co-Investigator(Kenkyū-buntansha) |
FURUTA Kazunori Kitasato Univ. School of Medicine, Dept, of Surgery, Research Associate, 医学部, 助手 (40209177)
TAKAHASHI Tsuyoshi Kitasato Univ. School of Medicine, Dept. of Surgery, Assistant Professor, 医学部, 講師 (70245405)
KAKITA Akira Kitasato Univ. School of Medicine, Dept. of Surgery, Professor, 医学部, 教授 (90109439)
SHIMADA Ken Kitasato Univ. School of Medicine, Dept, of Surgery, Research Associate, 医学部, 助手 (60216059)
HOSHINO Hiroki Kitasato Univ. School of Medicine, Dept. of Surgery, Research Associate, 医学部, 助手 (80276097)
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| Project Period (FY) |
2001 – 2003
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| Keywords | liver regeneration / pancreatic hormones / predictive indexes / liver failure / 耐術能 / 肝不全 |
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| Research Abstract |
In this study, we performed hepatectomy with pancreatectomy to assess the physiological contribution of the pancreas, especially in terms of endocrine function to hepatic regeneration. -five dogs were divided into the following four groups, group1 dogs underwent 70% hepatectomy alone, group2 dogs underwent with 66% pancreatectomy, group3 dogs underwent with 80% pancreatectomy, group4 dogs underwent with 95% pancreatectomy. While 4 week survival rate of the group1 was 100%, the survival rate decreased significantly in group2-4. The liver regeneration rate in group2,3 and 4 were also lower than those in group1. Changes on pancreatic hormones, such as insulin and glucagon, in a portal blood after the simultaneus resection of the liver and the pancreas depended on the size of the resected pancreas. Glucagon levels in the portal blood were especially increased in the group of hepatectomy with pancreatectomy. These results show that the pancreatic hormones affect the liver regeneration after the operation. In clinical practice, large scale simultaneous hepatectomy and pancreatectomy carries a high risk of postoperative hepatic insufficiency. Our present findings nay contribute to establishing prophylactic administration of glucagon and insulin to help stimulate the hepatic regeneration after evisceration.
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