2003 Fiscal Year Final Research Report Summary
Identification of genes on cDNA microarrays for prediction of sensitivity to anticancer drugs
| Project/Area Number |
13671406
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | KEIO UNIVERSITY |
|---|
Principal Investigator |
KAWAMURA Masafumi Keio University, School of Medicine, Assistant Professor, 医学部, 専任講師 (70169770)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Keiichi Keio University, School of Medicine, Assistant, 医学部, 助手 (30338066)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Keywords | microarray / non-small cell lung cancer / chemosensitivity / chemosensitivity test / CD-DST method / gene expression |
|---|
| Research Abstract |
To investigate genes related to sensitivity of non-small cell lung cancers (NSCLCs) to therapeutic drugs, we performed cDNA microarray analysis of 37 NSCLCs after laser-capture microdissection of cancer cells from primaru tumors resected by surgery. We compared expression data with measurements of the sensitivity of surgically resected NSCLC specimens to six anticancer drugs (docetaxel, paclitaxel, irinotecan, cisplatin, gemcitabine, and vinorelbine), as measured by the CD-DST (collagen gel droplet embedded culture drug sensitivity test) method. We found significant associations between expression levels of dozens of genes and chemosensitivity of NSCLCs in each anticancer agent.
|
