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2004 Fiscal Year Final Research Report Summary

Measuring the brain dynamics in several kind of disordered subjects by optical topography and its application to their treatment and educational training.

Research Project

Project/Area Number 14201013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionJapan Women's University

Principal Investigator

KAWACHI Juro  Japan Women's University, Faculty of Home Economics, Professor, 家政学部, 教授 (30083710)

Co-Investigator(Kenkyū-buntansha) KAWAMURA Mitsuru  SHOWA University, School of Medicine, Professor, 医学部, 教授 (20161375)
TORII Toshiko  Japan Women's University, Faculty of Integrated Arts and Social Sciences, Professor, 人間社会学部, 教授 (70060671)
DAIROKU Hitoshi  University of Tsukuba, Graduate School of Comprehensive Human Sciences, Lecturer, 人間総合科学研究科, 講師 (10251323)
ODA Kouichi  Tokyo Women's Christian University, Cultures, College of Culture and Communication, Professor, 現代文化学部, 教授 (60169307)
NOCHI Masahro  Tokyo Women's Christian University, College of Arts and Sciences, Associate Professor, 文理学部, 助教授 (30292717)
Project Period (FY) 2002 – 2004
Keywordsoptical topography / autism / word fluency test / Alzheimer disease / senile depression / Wisconsin Card Sorting Test / frontal area / laterality index
Research Abstract

One subject extensively studied was 29years old right handed autistic man. His intelligence scores were VIQ,57;PIQ,42:;FIQ,47. Although CT and MRI detected no dear lesion, SPECT confirmed low blood flow in the bilateral frontal areas. As expected, his performance of Wisconsin Card Sorting Test suggested frontal lobe dysfunction. But is language lateralization measured by optical topography during word fluency test showed ciear left hemisphere dominance as the normal subjects.
Mild ALzheimer disease(n=15), senile depression(n=5), and age matched normal subjects(n=22 were measured the blood flow in the frontal areas by optical topography during word fluency task. The mean numbers of words produced in 1 min. were 9.8,12.0. 14.2 respectively. The depressive group showed non significant reduction in word production, but their increase of hemoglobin in left frontal area during word fluency task was significantly smaller than the age matched normal subjects. On the contrary, the dementia group showed significant reduction in word production, but their increase of hemoglobin was not smaller than the normal subjects.
Brain activity during performing two kinds of language task (word fluency and syntax judgement) by optic topography in normal subjects.and it was found that the laterality indices of two tasks were highly correlated and distributed between the extreme left hemisphere dominannce and the extreme right hemisphere dominannce.

  • Research Products

    (14 results)

All 2004 2003 Other

All Journal Article (12 results) Book (2 results)

  • [Journal Article] Recognition of emotion from moving facial and prosodic stimuli in depressed patients.2004

    • Author(s)
      Kan Y, Mimura M, Kamijima K, Kawamura K
    • Journal Title

      Journal of Neurology, Neurosurgery, and Psychiatry 75・12

      Pages: 1667-1671

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An autopsied case of Sjogren's syndrome with massive necrotic and demyelinating lesions of the cerebellar white matter.2004

    • Author(s)
      Ichikawa H, Ishihara K, Fujimoto R, Katou T, Arai M, Kawamura M, Nakano I
    • Journal Title

      Journal of the Neurological Sciences 225・1-2

      Pages: 143-148

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration.2004

    • Author(s)
      Mochizuki-Kawai H, Kawamura M, Hasegawa Y, Mochizuki S, Oeda R, Yamanaka K, Tagaya H
    • Journal Title

      Neuropsychologia 42・13

      Pages: 1858-1863

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Recognition of emotion from moving facial and prosodic stimuli in depressed patients.2004

    • Author(s)
      Kan Y, Mimura M, Kamijima K, Kawamura M.
    • Journal Title

      Journal of Neurology, Neurosurgery, and Psychiatry 75(12)

      Pages: 1667-1671

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] An autopsied case of Sjogren's syndrome with massive necrotic and demyelinating lesions of the cerebellar white matter.2004

    • Author(s)
      Ichikawa H, Ishihara K, Fujimoto R, Katou T, Arai M, Kawamura M, Nakano I.
    • Journal Title

      Journal of the Neurological Sciences 225(1-2)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration.2004

    • Author(s)
      Mochizuki-Kawai H, Kawamura M, Hasegawa Y, Mochizuki S, Oeda R, Yamanaka K, Tagaya H.
    • Journal Title

      Neuropsychologia 42(13)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Right unilateral jargonagraphia as a symptom of callosal disconnection.

    • Author(s)
      Ihori N, Murayama J, Mimura M, Miyazawa Y, Kawamura M
    • Journal Title

      Cortex In press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A disconnection syndrome due to agenesis of the corpus callosum : Disturbance of unilateral synchronization.

    • Author(s)
      Midorikawa A, Kawamura M, Takaya R
    • Journal Title

      Cortex In press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 'Autistic' traits in non-autistic Japanese populations : relationships with personality traits and cognitive ability.

    • Author(s)
      Kunihira Y, Senjyu A, Dairoku H, Wakabayashi A, Hasegawa T
    • Journal Title

      Journal of Autism and Developmental disorders In press

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Right unilateral jargonagraphia as a symptom of callosal disconnection.

    • Author(s)
      Ihori N, Murayama J, Mimura M, Miyazawa Y, Kawamura M.
    • Journal Title

      Cortex (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A disconnection syndrome due to agenesis of the corpus callosum : Disturbance of unilateral synchronization.

    • Author(s)
      Midorikawa A, Kawamura M, Takaya R.
    • Journal Title

      Cortex (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ‘Autistic' traits in non-autistic Japanese Populations : relationships with personality traits and cognitive ability.

    • Author(s)
      Kunihira Y, Senjyu A, Dairoku H, Wakabayashi, A, Hasegawa T.
    • Journal Title

      (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 眼と精神2003

    • Author(s)
      彦坂興秀, 山鳥 重, 河村 満
    • Total Pages
      265
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] The eye and the mind.2003

    • Author(s)
      Hikosaka, O., Yamadori, A., Kawamura, M.
    • Total Pages
      265
    • Publisher
      Igaku-shoin
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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