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2004 Fiscal Year Final Research Report Summary

Development of a High Precision Three-Dimensional Modeling System for Biological Samples

Research Project

Project/Area Number 14205036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionThe University of Tokyo

Principal Investigator

HIGUCHI Toshiro  The University of Tokyo, Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (10111569)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Akio  The University of Tokyo, Graduate School of Engineering, Lecturer, 大学院・工学系研究科, 講師 (40313035)
KUDOH Ken-ichi  The University of Tokyo, Graduate School of Engineering, Research Associate, 大学院・工学系研究科, 助手 (90250232)
FUKUMORI Takeshi  SATAKE Co., Ltd., Executive Vice-President, Researcher, 取締役副社長
Project Period (FY) 2002 – 2004
KeywordsBioimaging / Micro-Slicer / 3-Dimensional Internal Structure Microscope
Research Abstract

Using a Micro-Slicer Image Processing System, which consists of a rotary blade and automatic sample feeding mechanism, biological samples such as food and internal organs have been observed. It became possible to observe the distribution of ice crystals formed in frozen foods and biological materials with this system. To observe the distribution of ice crystals a fluorescence stain was used and an optimal wavelength of light was selected. The processes and results were presented in prepublication papers shown below.
・Quantitative Analysis of Ice Crystals Formed in Frozen Food (Japanese Society for Cryobiology and Cryotechnology)
・Three-Dimensional Measurement of Ice Crystals in Frozen Dilute Solutions (Japan Society of Refrigerating and Air conditioning Engineers)
・None-destructive Measurement of Ice Crystals in Frozen Gelatin Gel-Estimation of Ice Crystal Structure by Utilizing Dielectric Properties-(Japan Society of Refrigerating and Air conditioning Engineers)
An award was given for the paper of "None-destructive Measurement of Ice Crystals in Frozen Gelatin Gel" by Japan Society of Refrigerating and Air conditioning Engineers.
A new type of Micro-sheer image processing system was proposed. A linear motor moves a slicing blade. This system is not equipped with a CCD camera and lens, but it uses an image scanner for image acquisition. In this system, a sample is sliced and the images of sliced sample are acquired automatically and continuously. Compared with the conventional systems, the images of the sliced sample are acquired with a high degree of accuracy because the sample is illuminated uniformly. Furthermore, the system is more compact because translatory movement of a slicing blade does not need as much space as the rotary movement. After the acquisition of imge data of each sliced sample, a three dimensional image, showing the internal information of the biological sample, can be reconstructed on a computer.

  • Research Products

    (9 results)

All 2005 2004 2002

All Journal Article (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] リニアマイクロスライサを用いた生体内部観察システムの開発2005

    • Author(s)
      工藤謙一, 木下泰希, 樋口俊郎
    • Journal Title

      日本エム・イー学会 生体医工学 Vol.43 No.1

      Pages: 103-108

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of an Internal Observation System for Biological Samples Using a Linear Micro-slicer2005

    • Author(s)
      Ken-ichi KUDOH, Taiki KINOSHITA, Gab-soo DO, Manzo UCHIGASAKI, Kahei SATO, Toshiro HIGUCHI
    • Journal Title

      Trans.of the JSMBE Vol.43, No.1

      Pages: 103-108

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 凍結ゼラチンゲル内氷結晶の非破壊計測法に関する研究2004

    • Author(s)
      上野茂昭, 白樫 了, 都 甲沫, 相良泰行, 工藤謙一, 樋口俊郎
    • Journal Title

      日本冷凍空調学会論文集 Vol.21 No.4

      Pages: 337-344

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] None-destructive Measurement of Ice Crystals in Frozen Gelatin Gel-Estimation of Ice Crystal Structure Structure by Utilizing Dielectric Properties-2004

    • Author(s)
      Shigeaki UENO, Ryo SHIRAKASHI, Gab-soo DO, Yasuyuki SAGARA, Ken-ichi KUDOH, Toshiro HIGUCHI
    • Journal Title

      Trans.of the JSRAE Vol.21, No.4

      Pages: 337-344

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 食品の凍結により形成される氷結晶性状の定量的解析2002

    • Author(s)
      上野茂昭, 都 甲沫, 相良泰行, 工藤謙一, 樋口俊郎
    • Journal Title

      低温生物工学会誌 Vol.48 No.2

      Pages: 99-102

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 希薄溶液系材料内氷結晶の3次元計測法に関する研究2002

    • Author(s)
      上野茂昭, 都 甲沫, 相良泰行, 工藤謙一, 樋口俊郎
    • Journal Title

      日本冷凍空調学会論文集 Vol.19 No.4

      Pages: 381-387

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Quantitative Analysis of Ice Crystals Formed in Frozen Food2002

    • Author(s)
      Shigeaki UENO, Gab-soo DO, Yasuyuki SAGARA, Ken-ichi KUDOH, Toshiro HIGUCHI
    • Journal Title

      Cryobiology and Cryotechnology Vol.48, No.2

      Pages: 99-102

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Three-Dimensional Measurement of Ice Crystals in Frozen Dilute Solutions2002

    • Author(s)
      Shigeaki UENO, Gab-soo DO, Yasuyuki SAGARA, Ken-ichi KUDOH, Toshiro HIGUCHI
    • Journal Title

      Trans.of the JSRAE Vol.19, No.4

      Pages: 381-387

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 試料観察面製作機能を具備するイメージ情報取得装置2004

    • Inventor(s)
      樋口 俊郎, 工藤 謙一, 多田 茂也
    • Industrial Property Rights Holder
      日本国
    • Industrial Property Number
      平願2004-35857
    • Filing Date
      2004-02-13
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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