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2003 Fiscal Year Final Research Report Summary

Radiation Sensitivity and Mitochondrial Related Responding Genes.

Research Project

Project/Area Number 14207078
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 病態科学系歯学(含放射線系歯学)
Research InstitutionKagoshima University

Principal Investigator

MAJIMA Hideyuki  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (60165701)

Co-Investigator(Kenkyū-buntansha) SATO Tsuyoshi  Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (90136888)
OZAWA Toshihiko  National Institute of Radiological Sciences, Redox Regulation Research Group, Researcher, 研究員 (40160858)
MARUYAMA Ikuro  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (20082282)
TOMITA Kazuo  Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院・医歯学総合研究科, 助手 (60347094)
SUENAGA Shigeaki  Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (00136889)
Project Period (FY) 2002 – 2003
KeywordsRadiosensitivity / Mitochondria / Radiation response gene / DNA array method
Research Abstract

We examined whether lack of mitochondrial DNA affects gene expression using DNA microarray analysis, to compare mRNA expression between Rho 0 cells and the parental cells, 143B. The results showed that lack of mitochondrial DNA could cause significant increases in chaperon genes in Rho 0 cells.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] H.Kariyazono: "Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood."Blood Coagulation & Fibrinolysis. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Hirai: "Mitochondrial Signal Lacking Manganese Superoxide Diamutase Failed to Prevent Cell Death by Reoxygenation following Hypoxia in a Human Pancreatic Cancer Cell Line, KP4."Antioxidant & Redox Signaling. 6(3). 523-535 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kakinuma: "Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas."Biological Sciences in Space. 17(3). 187 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.-C.Yen: "Increase of Lipid Peroxidation by Cisplatin in WI38 but not in SV40-transformed WI38 cells."J.Biochem.Mol.Toxicol.. 17(1). 1-8 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Setsukinai: "Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species."J.Biol.Chem,. 278(5). 3170-3175 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anzai K: "ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes."Arch.Biochem.Biophys.. 415(2). 251-256 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura Y: "Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice."J.Radiat.Res.. 44(1). 53-58 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Koike: "Relative biological effectiveness of 290 McV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma."J.Radiat.Res.. 43(3). 247-225 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.J.Majima: "4-hydroxy-2-nonenal (4-HNE) staining by anti-HNE antibody."Methods Mol Biol. 196. 31-34 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kariyazono H, Nakamura K, Arima J, Ayukawa O, Onimaru S, Masuda H, Iguro Y, Majima HJ, Ryuzo Sakata R, Yamada K: "Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood."Blood Coagulation & Fibrinolysis. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirai F, Motoori S, Kakinuma S, Tomita K, Indo HP, Kato H, Yamaguchi T, Yen H-C, St.Clair DK, Nagano T, Ozawa T, Saisho H, Majima HJ: "Mitochondrial Signal Lacking Manganese Superoxide Dismutase Failed to Prevent Cell Death by Reoxygenation following Hypoxia in a Human Pancreatic Cancer Cell Line, KP4."Antioxidant & Redox Signaling. 6(3). 523-535 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kakinuma S, Kubo A, Amasaki Y, Nojima K, Monobe M, Majima H, Imaoka T, Nishimura M, Shimada Y: "Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas."Biological Sciences in Space. 17(3). 187 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yen H-C, Nien C-Y, Majima HJ, Lee C-P, Chen S-Y, Wei J-S: "Increase of Lipid Peroxidation by Cisplatin in WI38 but not in SV40-transformed WI38 cells."J.Biochem.Mol.Toxicol.. 17(1). 39-46 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setsukinai K, Urano Y, Kakinuma K, Majima HJ, Nagano T: "Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species."J.Biol.Chem.. 278(5). 3170-3175 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura Y, Kim HS, Ikota N, Arima H, Bom HS, Kim YH, Watanabe Y, Yukawa M, Ozawa T.: "Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice."J.Radiat.Res.. 44(1). 53-58 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anzai K, Aikawa T, Furukawa Y, Matsushima Y, Urano S, Ozawa T.: "ESR measurement of rapid penetration of DMPO and DEPMPO spin traps through lipid bilayer membranes."Arch.Biochem.Biophys.. 415(2). 251-256 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koike S, Ando K, Oohira C, Fukawa T, Lee R, Takai N, Monobe M, Furusawa Y, Aoki M, Yamada S, Shimizu W, Nojima K, Majima H: "Relative biological effectiveness of 290 MeV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma."J.Radiat.Res.. 43(3). 247-255 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Majima HJ, Nakanishi-Ueda T, Ozawa T: "4-hydroxy-2-nonenal (4-HNE) staining by anti-HNE antibody."Methods Mol.Biol.. 196. 31-34 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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