2004 Fiscal Year Final Research Report Summary
Clinical and Basic Research of Dementia with Lewy bodies
| Project/Area Number |
14370293
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
MIURA Satashi Yokohama City Univ., Medical, Associate Prof., 医学部, 助教授 (60157427)
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| Co-Investigator(Kenkyū-buntansha) |
ISEKI Eizo Juntenndo Univ., School of Medicine, Associate Prof., 医学部, 助教授 (30203061)
KOSAKA Kenji Yokohama City Univ., Medical, Honorary Prof., 医学部, 名誉教授 (60023800)
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| Project Period (FY) |
2002 – 2004
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| Keywords | dementia with Lewy bodies / Parkinson's disease with dementia / Alzheimer's disease / visual cognitive impairments / autonomic disturbances / denepezil chloride / Lewy body / α-synuclein |
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| Research Abstract |
1) Clinical researches:
We studied clinical findings in DLB patients, and disclosed the following points;
・Various visual cognitive impairments including visual hallucination, visual illusion, metamorphopsia and Capras syndrome are frequently present.
・Autonomic disturbances including constipatio, and urinary incontinenia are so frequently found as in PD patients.
・MRI shows usually mild to moderate atrophy in the medial temporal region, and SPELT indicates frequent, although not specific, decrease of rCBF in the occipital lobes.
2) Neuropathological researches:
We studied many DLB brains neuropathologically, and got the following results.
・DLB(18%) was the third most frequent dementing illness following AD(43%) and VD(23%) in our geriatric hospital.
・Lewy pathology was divided into 4 stages, and DLB cases with AD pathology had the 3^<rd> and 4^<th> stages. In addition, Lewy pathology was indicated to advance from the amygdala through the limbic cortex to the neocortex.
・In the hippocampus, Lewy bodies occur first in the CA3-4, while NFTs in the CAI.
・Recent immunostaining reconfirmed our previous findings showing a close relationship between Lewy bodies and nerve cell loss, and disclosed marked RNA oxidation and occurrence of cytokines and metric oxide synthase in the DLB brain.
・TH-positive neurons are apt to degenerate in the cerebral cortex and hippocampus of the DLB brain.
Recent immunohistochemistry of Lewy pathology and Alzheimer pathology diffwrentiates DLB from AD.
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[Journal Article] Serum ghrelin concentrations in patients receiving olanzapine or rispedorine2004
Author(s)
Togo, T., Hasegawa, K., Miura, S., Hosogima, H., Kojima, K., Shoji, M., Kase, A., Uchikado, H., Iseki, E., Kosaka, K.
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Journal Title
Psychophanmacology 172
Pages: 230-232
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Dementia with Lewy bodies from the perspective of tauropathy2003
Author(s)
Iseki, E., Togo, T., Suzuki, K., Katsuse, O., Marui, W., de Silva, R., Lee, A., Yamamoto, T., Kosaka, K.
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Journal Title
Acta Neuropathol. 105
Pages: 265-270
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies2003
Author(s)
Nunomura, A., Chiba, S., Kosaka, K., Takeda, A., Castellani, R.J., Smith, M., Perry, G.
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Journal Title
Clin. Neurosci. Neuropatholo. 13
Pages: 2035-2039
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia2003
Author(s)
Horimoto, Y., Matsumoto, M., Nakagawa, H., Yoasa, H., Morishima, M., Akatsu, H., Ikari, H., Yamamoto, Y., Kosaka, K.
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Journal Title
J. Neurol. 250
Pages: 530-533
Description
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[Journal Article] Immunohistochemical study of synphilin 1 in brains of patients with dementia with Lewy bodies-Synphilin 1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions2002
Author(s)
Iseki, E., Takayama, N., Furukawa, Y., Marui, W., Nakai, T., Miura, S., Ueda, K., Kosaka, K.
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Journal Title
Neurosci. Lett. 326
Pages: 211-215
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies2002
Author(s)
Marui, W., Iseki, E., Nakai, T., Miura, S., Kato, M., Ueda, K., Kosaka, K.
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Journal Title
Neurol. Sci. 195
Pages: 153-159
Description
「研究成果報告書概要(欧文)」より
