2003 Fiscal Year Final Research Report Summary

Molecular Pathological study of Carcinogenesis and behaeiviors of oral cancer.

Research Project

Project/Area Number	14370578
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Morphological basic dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TAKAGI Minoru Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (30014012)
Co-Investigator(Kenkyū-buntansha)	SAKAMOTO Kei Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Assistant, 大学院・医歯学総合研究科, 助手 (00302886) KATSUBE Kenichi Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Lecturer, 大学院・医歯学総合研究科, 講師 (20233760)
Project Period (FY)	2002 – 2003
Keywords	oral cancer / leukoplakia / human papilloma virus / papilloma / epidemiology / molecular pathology / carcinogenesis / immunohistocheniistry
Research Abstract	(1) Molecular pathological studies of human papilloma virus (HPV) of oral carcinoma, leukoplakia, papilloma, dysplasia were performed. The data of HPV was correlated with pathological behaviors of these lesions. (2) Epidemiological study was performed in the Miyakojiina Okinawa, in order to detect the percentage of HPV infection in the normal oral mucosa. The percentage of infection was low but rare types were discovered. (3) Prevalency of HPV in the oral cancer was studied in Myanmar, China and Sri-Lanka. (4) Interrelationship among HPV detection, betal quid and oral cancer was studied in Myanmar.

Research Products
(19 results)

All Other

All Publications (19 results)

[Publications] 黒瀬和代, 寺井政憲, 高木実, 他: "Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan."Oral Surg Oal Med Pathol Endod. 97. (2004)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Liu Y, Tran Tu Ngoc, Okada N, Takagi M: "Pathogenesis of multiple squamous cell carcinomas in oral cavity : Clinicopathological and Immunohistological study of 31 patinents."Oral Med Pathol. 8. 75-82 (2003)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Nishioka M, Swe Swe Win, Ba Myint, Takagi M: "Detection of p53,Bax, Rb, p16 and human paillomavirus DNA in betel quid associated pral squamous cell carcinoma in Myammer."Oral Med Pathol. 8. 7-11 (2003)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Esgurerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M.: "Immunohisutochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma."Pathology International. 54. 82-89 (2004)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Esguerra RL, Jia L, Takagi M et al.: "Comparative Analysis of Oral Cancer Among Filipinos in the philippines and Migrant Filipinos."Oral Med Pathol. 9. (2004)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Jia L, Esguerra RL, Sakamoto K, Okada N, Takagi M, et al.: "Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenois cystic carcinoma."Pathology International. 54. 217-223 (2004)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Chuai M-L, Sakamoto K, Okada N, Yamamoto H, Takagi M et al.: "Expression of VEGF, VEGF-R2,bFGF and FGF-R in oral capillary hemangioma."Oral Med.Pathol. 8. 83-89 (2003)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Misaki A, Sakamoto K, Okada N, Takagi M: "Immunohistochemical examination of Patched and Sonic hedgehog in odontogenic keratocysts associated with basal cell nevus syndrome."Oral Med Pathol. (印刷中). (2004)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Tang X, Jia L, Ouyang J, Takagi M.: "Comparative study of HPV prevalence in Japanese Northeast Chinese oral carcinoma."J Oral Pathol. 32. 393-398 (2003)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Primali R Jayasooriya, Kurose K, Terai M, Takagi M et al.: "Human papillomavirus oral cancer from Sri-Lanka : Prevalence and relationship with Clinico-pathological parameters."Oral Med Pathol. 8. 45-50 (2003)
- Description
  「研究成果報告書概要(和文)」より
[Publications] Kurose K, Terai M, Nurtami, Rabello D, Nakajima Y, Burk R, Takagi M.: "Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan."Oral Surg Oral Med Oral Pathol Endod. 97. (2004)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Liu Y, Tran Tu Ngoc, Okada N, Takagi M.: "Pathogenesis of multiple squamous cell carcinomas in oral cavity Clinicopathological and Immunohistological study of 31 patients."Oral Med Pathol. 8. 75-82 (2003)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Nishioka M, Swe Swe Win, Ba Myint, Takagi M.: "Detection of p53, Bax, Rb, p16 and human papillomavirus DNA in betel quid associated oral squamous cell carcinoma in Myanmar."Oral Med Pathol. 8. 7-11 (2003)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Esguerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M.: "Immunohisutochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinomas"Pathology. 54. 82-89 (2004)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Esguerra RL, Jia L, Tudtud HE, Alvez PJ, Shiraki S, Sakamoto K, Takagi M.: "Comparative Analysis of Oral Cancer Among Filipinos in the Philippines and Migrant Filipinos."Oral Med Pathol. 9. (2004)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Jia L, Esguerra RL, Tang X, Yin H, Sakamoto K, Okada N, Takagi M.: "Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma."Pathology International. 54. 217-223 (2004)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Chuai M-L, Sakamoto K, Iseki H, Makino T, Okada N, Yamamoto H, Takagi M.: "Expression of VEGF, VEGF-R2, bFGF and FGF-R in oral capillary hemangioma."Oral Med.Pathol. 8. 83-89 (2003)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Tang X, Jia L, Ouyang J, Takagi M.: "Comparative study of HPV prevalence in Japanese and Northeast Chinese oral carcinoma."J Oral Pathol. 32. 393-398 (2003)
- Description
  「研究成果報告書概要(欧文)」より
[Publications] Primali R Jayasooriya, Kurose K, Terai M, Kandavanam Sivagnanam, Samadarani Siriwardana, Wanninayaka Mudiyansalage Tilakaratne, Tagami J, Takagi M.: "Human papillomavirus in oral cancer from Sri-Lanka: Prevalence and relationship with Clinico-pathological parameters."Oral med Pathol. 8. 45-50 (2003)
- Description
  「研究成果報告書概要(欧文)」より

2003 Fiscal Year Final Research Report Summary

Molecular Pathological study of Carcinogenesis and behaeiviors of oral cancer.

Principal Investigator

TAKAGI Minoru Tokyo Medical and Dental University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (30014012)

Research Products

[Publications] 黒瀬和代, 寺井政憲, 高木 実, 他: "Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan."Oral Surg Oal Med Pathol Endod. 97. (2004)

Description

[Publications] Liu Y, Tran Tu Ngoc, Okada N, Takagi M: "Pathogenesis of multiple squamous cell carcinomas in oral cavity : Clinicopathological and Immunohistological study of 31 patinents."Oral Med Pathol. 8. 75-82 (2003)

Description

[Publications] Nishioka M, Swe Swe Win, Ba Myint, Takagi M: "Detection of p53,Bax, Rb, p16 and human paillomavirus DNA in betel quid associated pral squamous cell carcinoma in Myammer."Oral Med Pathol. 8. 7-11 (2003)

Description

[Publications] Esgurerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M.: "Immunohisutochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma."Pathology International. 54. 82-89 (2004)

Description

[Publications] Esguerra RL, Jia L, Takagi M et al.: "Comparative Analysis of Oral Cancer Among Filipinos in the philippines and Migrant Filipinos."Oral Med Pathol. 9. (2004)

Description

[Publications] Jia L, Esguerra RL, Sakamoto K, Okada N, Takagi M, et al.: "Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenois cystic carcinoma."Pathology International. 54. 217-223 (2004)

Description

[Publications] Chuai M-L, Sakamoto K, Okada N, Yamamoto H, Takagi M et al.: "Expression of VEGF, VEGF-R2,bFGF and FGF-R in oral capillary hemangioma."Oral Med.Pathol. 8. 83-89 (2003)

Description

[Publications] Misaki A, Sakamoto K, Okada N, Takagi M: "Immunohistochemical examination of Patched and Sonic hedgehog in odontogenic keratocysts associated with basal cell nevus syndrome."Oral Med Pathol. (印刷中). (2004)

Description

[Publications] Tang X, Jia L, Ouyang J, Takagi M.: "Comparative study of HPV prevalence in Japanese Northeast Chinese oral carcinoma."J Oral Pathol. 32. 393-398 (2003)

Description

[Publications] Primali R Jayasooriya, Kurose K, Terai M, Takagi M et al.: "Human papillomavirus oral cancer from Sri-Lanka : Prevalence and relationship with Clinico-pathological parameters."Oral Med Pathol. 8. 45-50 (2003)

Description

[Publications] Kurose K, Terai M, Nurtami, Rabello D, Nakajima Y, Burk R, Takagi M.: "Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan."Oral Surg Oral Med Oral Pathol Endod. 97. (2004)

Description

[Publications] Liu Y, Tran Tu Ngoc, Okada N, Takagi M.: "Pathogenesis of multiple squamous cell carcinomas in oral cavity Clinicopathological and Immunohistological study of 31 patients."Oral Med Pathol. 8. 75-82 (2003)

Description

[Publications] Nishioka M, Swe Swe Win, Ba Myint, Takagi M.: "Detection of p53, Bax, Rb, p16 and human papillomavirus DNA in betel quid associated oral squamous cell carcinoma in Myanmar."Oral Med Pathol. 8. 7-11 (2003)

Description

[Publications] Esguerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M.: "Immunohisutochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinomas"Pathology. 54. 82-89 (2004)

Description

[Publications] Esguerra RL, Jia L, Tudtud HE, Alvez PJ, Shiraki S, Sakamoto K, Takagi M.: "Comparative Analysis of Oral Cancer Among Filipinos in the Philippines and Migrant Filipinos."Oral Med Pathol. 9. (2004)

Description

[Publications] Jia L, Esguerra RL, Tang X, Yin H, Sakamoto K, Okada N, Takagi M.: "Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma."Pathology International. 54. 217-223 (2004)

Description

[Publications] Chuai M-L, Sakamoto K, Iseki H, Makino T, Okada N, Yamamoto H, Takagi M.: "Expression of VEGF, VEGF-R2, bFGF and FGF-R in oral capillary hemangioma."Oral Med.Pathol. 8. 83-89 (2003)

Description

[Publications] Tang X, Jia L, Ouyang J, Takagi M.: "Comparative study of HPV prevalence in Japanese and Northeast Chinese oral carcinoma."J Oral Pathol. 32. 393-398 (2003)

Description

Description

[Publications] 黒瀬和代, 寺井政憲, 高木実, 他: "Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan."Oral Surg Oal Med Pathol Endod. 97. (2004)