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2004 Fiscal Year Final Research Report Summary

Study of endurance training effects on anti-oxidative activity.

Research Project

Project/Area Number 14380022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionIncorporated administrative agency National Institute of Health and Nutrition

Principal Investigator

KUMAE Takashi  National Institute of Health and Nutrition, Health Promotion and Exercise, Chief, 健康増進研究部, 室長 (40145363)

Co-Investigator(Kenkyū-buntansha) ARAKAWA Hatsuko  National Institute of Public Health, Education Training Technology and Development, Chief, 研修企画部, 室長 (90222736)
Project Period (FY) 2002 – 2004
KeywordsEndurance Exercise / Anti-oxidative Activity / Reactive Oxygen Species / Chemiluminescence / Phagocyte / Cytokine / Long-distance Run / Habitual Physical Exercise
Research Abstract

One characteristic point of this study is that we establish a simple and convenient method to measure levels of total anti-oxidative activity(TAA) in serum based upon a hypothesis that antioxidants will act synergistically and cooperatively in vivo. The other point in this study is to establish a reliable measurement method of reactive oxygen species(ROS) generated by phagocytes.
The antioxidants in a rat broncho-alveolar lavage fluid(BALF) were measured to estimate oxidative stress. It is thought that in BALF, the protein and the thiobarbituric acid reactive materials(TBAR) level are good marker for acute and long term stress, respectively. Different effects between forced and voluntary training on rats were revealed by measurements of ROS generating capability of alveolar macrophage(AM) and levels of IL-1β,IFNγ,and TNFα,in AM cultured mediums.
Effects of marathon race on civilian runners were investigated. Significant increases were observed in the neutrophil numbers and levels of IL-6,IL-8,and G-CSF after the race. The nuetrophilic functions and the expressions of CD11b and CD16 were measured on runners run completely the race. Results suggest that the nuetrophilic functions are suppressed after the race and increment of neutrophil number may be compensatory effects of decreased functions. The antioxidants, TAA, and cytokine levels of female long-distance runner were measured to investigate effects of a summer camp. Significant positive correlation was observed between TAA and TBAR levels. According to changes of cytokine levels, systemic inflammatory response is suppressed and Th2 activity may be down regulated. Effects of habitual exercise on serum antioxidant levels in older residents in a rural area were studied. Significant positive correlation is observed between TAA and TBAR levels in a group of males with a habitual physical exercise.
These results suggest that TAA is a useful marker to estimate an anti-oxidative status in serum.

  • Research Products

    (14 results)

All 2005 2004 2003 2002

All Journal Article (13 results) Book (1 results)

  • [Journal Article] Effects of forced exercise started from different ages on chemiluminescent response and cytokine excretion of alveolar macrophage.2005

    • Author(s)
      Kumae T
    • Journal Title

      Bioluminescence & Chemiluminescence Progress and Perspectives(Tsuji A, Matsumoto M, Maeda M, Kricka LJ, Stanley PE.eds.)(World Scientific, Singapore)

      Pages: 307-310

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of a simple and reliable method to measure totalanti-oxidative activity in human sera using parallel luminometer2004

    • Author(s)
      Kumae T
    • Journal Title

      J Phys Fit Nutr Immunol 14

      Pages: 87-97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 地域在住高齢者の血清中抗酸化物質と酸化・抗酸化バランスに及ぼす運動習慣の影響に関する研究2004

    • Author(s)
      熊江 隆
    • Journal Title

      体力・栄養・免疫学雑誌 14

      Pages: 240-249

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of a simple and reliable method to measure totalanti-oxidative activity in human sera using parallel luminometer.2004

    • Author(s)
      Kumae T
    • Journal Title

      J Phys Fit Nutr Immunol 14

      Pages: 87-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Study of habitual exercise effects on serum anti-oxidant levels and an oxidative and anti-oxidative balance in older residents in a rural area.2004

    • Author(s)
      Kumae T
    • Journal Title

      J Phys Fit Nutr Immunol 14

      Pages: 240-249

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Assessment of training effects on activity levels of alveolar macrophage in matured rats using chemiluminescent technique2003

    • Author(s)
      Kumae T
    • Journal Title

      Luminescence 18

      Pages: 61-66

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Impact of a competitive marathon race on systemic cytokine and neutrophil responses2003

    • Author(s)
      Suzuki K
    • Journal Title

      Med Sci Sports Exer 35

      Pages: 348-355

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A competitive marathon race decreases neutrophil function in athletes2003

    • Author(s)
      Chinda D
    • Journal Title

      Luminescence 18

      Pages: 324-329

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Assessment of training effects on activity levels of alveolar macrophage in matured rats using chemiluminescent technique.2003

    • Author(s)
      Kumae T
    • Journal Title

      Luminescence 18

      Pages: 61-66

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Impact of a competitive marathon race on systemic cytokine and neutrophil responses.2003

    • Author(s)
      Suzuki K
    • Journal Title

      Med Sci Sports Exer 35

      Pages: 348-355

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] competitive marathon race decreases neutrophil function in athletes.2003

    • Author(s)
      Chinda D
    • Journal Title

      Luminescence 18

      Pages: 324-329

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 男子大学生の長距離走選手における体格及び練習量の9ヶ月間の変動と摂取栄養素量の夏冬の比較2002

    • Author(s)
      熊江 隆
    • Journal Title

      体力・栄養・免疫学雑誌 12

      Pages: 87-95

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Changes of physical characteristics and training during 9 months and comparison of nutritional intakes between summer and winter in male university long-distance runners.2002

    • Author(s)
      Kumae T
    • Journal Title

      J Phys Fit Nutr Immunol 12

      Pages: 87-95

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Bioluminescence & Chemiluminescence Progress and Perspectives(Tsuji A, Matsumoto M, Maeda M, Kricka LJ, Stanley PE. eds)2005

    • Author(s)
      Kumae T
    • Total Pages
      568(307-310)
    • Publisher
      World Scientific, Singapore
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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