2003 Fiscal Year Final Research Report Summary
Development of myosin isoform function in single ventricular myocytesHeart
| Project/Area Number |
14570046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Teikyo University |
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Principal Investigator |
SUGI Haruo Teikyo University, School of Medicine, Professor, 医学部, 教授 (20082076)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Hiroshi University of Tokyo, Department of Medicine, Instructor, 医学部, 助手 (50323572)
KOBAYASHI Takakazu Shibaura Institute of Technology, Department of Technology, Professor, 工学部, 教授 (00112756)
SUGIURA Seiryo University of Tokyo, Graduate school of Frontier Science, Professor, 新領域創生科学研究科, 教授 (10272551)
SHIRAKAWA Ibuki Teikyo University, School of Medicine, Instructor, 医学部, 助手 (80236190)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Heart / Ventricular myocyte / Myosin isoform / Muscle contraction / Laser optical trap / ATP |
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| Research Abstract |
Rat ventricle normally contains a-rnyosin heavy chain isoforms, and if exposed to ventricular overload, they are replaced by n-heavy chain isoforms, to result in a decrease in tension cost. Human ventricle, on the other hand, only consists of β-myosin heavy chain isoforms, and the isoform composition does not change under the condition of ventricular overload.
To given information about the mode of adaptation of human ventricle to overload, we studied the effect of changing the myosin light chain isoforms on the motor function of ventricular myosin. We found that myosin light chain isoforms actually affects the magnitude of force exerted by each ventricular myosin molecule.
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[Publications] Yamashita, H., Sugiura, S., Fujita, H., Yasuda, S., Nagai, R., Saeki, Y., Sunagawa, K., Sugi, H.: "Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction."Cardiovascular Research. 60・3. 580-588 (2003)
Description
「研究成果報告書概要(和文)」より
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[Publications] Yasuda, S., Sugiura, S., Yamashita, H., Nishimura, S..Saeki, Y., Momomura, S., Katoh, K., Nagai, R., Sugi, H.: "Unloaded shortening increases peak of Ca^<2+> transients but accelerates their decay in rat single cardiac myocytes."American Journal of Physiology - Heart and Circulatory Physiology. 285. H470-H475 (2003)
Description
「研究成果報告書概要(和文)」より
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[Publications] Yamashita, H., Sugiura, S., Fujita, H., Yasuda, S., Nagai, R., Saeki, Y., Sunagawa, K., Sugi, H.: "Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction"Cardiovascular Research. 60(3). 580-588 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yasuda, S., Sugiura, S., Yamashita, H., Nishimura, S., Saeki, Y., Momomura, S., Katoh, K., Nagai, R., Sugi, H.: "Unloaded shortening increases peak of Ca^<2+> but accelerates their decay in rat single cardiac myocytes"American Journal of Physiology -Heart and Circulatory Physiology. 285. H470-H475 (2003)
Description
「研究成果報告書概要(欧文)」より
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