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2003 Fiscal Year Final Research Report Summary

API2-MALT1 translocation and tumorgenesis in gastric MALT lymphoma

Research Project

Project/Area Number 14570437
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

SUGIYAMA Toshiro  Hokkaido University, Graduate School of Medicine, Prof., 大学院・医学研究科, 助教授 (00196768)

Co-Investigator(Kenkyū-buntansha) ASAKA Masahiro  Hokkaido University, Graduate School of Medicine, Prof., 大学院・医学研究科, 教授 (10113507)
Project Period (FY) 2002 – 2003
KeywordsH.pylon / Gastric MALT lymphoma / API2-MALT1 chimeric transcript / NF-kB activation
Research Abstract

Total gastrectomy was an established conventional treatment against gastric MALT lymphoma. As the 60-80% of gastric MALT lymphoma regress by an eradication treatment of H.pylon and the remaining 20-40% does not, the predictive factor to eradication treatment should be clinically identified. The translocation between API2 gene in Ch11 and MALT1 gene in Ch18 was observed in a part of gastric MALT lymphoma and the high sensitive detection method of the chimeric transcript was established By using this system, the presence of API2-MALT1 chimeric transcript was an important predictive factor to resist for eradication treatment. These results suggest us that the presence of API2-MALT1 chimeric transcript might have a causal linkage to occurrence of eradication-resistant gastric MALT lymphoma. The transfection of API2-MALT1 chimeric cDNA into COS7 cells have induced an accumulation of the chimeric protein within the cytoplasm and demonstrated the delayed degradation of the protein. The accumulation of the chimeric protein within the cytoplasm resulted in an activation of NF-kB in the nucleus. Therefore, the presence of API2-MALT1 chimenc transcript might have a causal linkage to tumorgenesis via NF-kB activation in eradication-resistant gastric MALT lymphoma.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Ishizuka J Sugiyama T, et al.: "Molecular cloning of p53 of Mongolian gerbil and establishment of yeast functional assay system"Helicobacter. 8. 81-89 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasako T, Sugiyama T, et al.: "Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Marchildon PA, Sugiyama T: "Evaluation of the effects of strain-specific antigen variation on the accuracy of sero-diagnosis of Helicobacter pylori Infection"J Clin Microbiol. 41. 1480-1485 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugiyama T, Asaka M: "Molecular basis for development of gastric cancer -in vivo and in vitro study-"Keiio J Med. 51. 57-62 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugiyama T, et al.: "H.Pylori eradication for intractable gastric ulcer"Aliment Pharmacol Ther. 18. 543-544 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higashi H, Sugiyama T, et al.: "SHP-2 tyrosine phosphatase as an intracellular target of H.pylori CagA protein"Science. 295. 683-686 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishizuka J, Sugiyama T, Hirayama F, Tada M, Moriuchi T, Asaka M: "Molecular cloning of p53 of Mongolian gerbil and establishment of yeast functional assay system"Helicobacter. 8. 81-89 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasako T, Sugiyama T, Mizushima T, Miura Y, Asaka M: "Upregulated Smad 5 mediates apoptosis of gastric epithelial cells induced by H.pylori infection"J Biol Chem. 278. 4821-4825 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Marchildon PA, Sugiyama T, Fukuda Y.Asaka M, Shimoyama T, Graham, DY: "Evaluation of the effects of strain-specific antigen variation on the accuracy of serologic diagnosis of Helicobacter pylori lnfection"J Clin Microbiol. 41. 1480-1485 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugiyama T, Asaka M.: "Molecular basis for development of gastric cancer -in vivo and in vitro study-"Keiio J Med. 51. 57-62 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugiyama T, Asaka M: "H.pylori eradication for intractable gastric ulcer"Aliment Pharmacol Ther. 18. 543-544 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M.: "SHP-2 tyrosine phosphatase as an intracellular target of H.pylori CagA protein."Science. 295. 683-686 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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