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2003 Fiscal Year Final Research Report Summary

Endoplasmic reticulum stress-induced apoptosis in pre-necrotic period in skeletal muscles of laminin-2 deficiency

Research Project

Project/Area Number 14570605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

IKEZOE Koji  KYUSHU UNIVERSITY, Hospital, Research Associate, 大学病院, 助手 (80343317)

Co-Investigator(Kenkyū-buntansha) FURUYA Hirokazu  KYUSHU UNIVERSITY, Graduated School of Medical Sciences, Associate Professor, 大学院・医学研究院, 助教授 (60253415)
TAKEDA Shinichi  National Center of Neurology and Psychiatry, Institute of Neurosciencies, Head, 神経研究所, 部長(研究職) (90171644)
Project Period (FY) 2002 – 2003
Keywordsapoptosis / laminin-2 / merosin / anoikis / Bad / caspase-12 / ER stress
Research Abstract

Abortive regeneration process following massive necrosis in perinatal period causes dystrophic changes in laminin-2 deficient skeletal muscles. Although this apoptotic muscle fiber loss seems to be anchorage-dependent or anoikis, defective signaling pathways resulting in apoptosis have not been identified, yet.
In this study, we examined the signaling pathways disturbed in regenerating fibers of dy3K/dy3K, a null mutant mouse for laminin a2 chain. Regenerating fibers of dy3K/dy3K showed phosphorylation of Ser 112 and 135 of Bad, but of Ser 155. Ser 155 of Bad is phosphorylated via activation of PKA. Therefore, it is possible that the survival signaling pathway via PKA is disturbed in regenerating fibers of dy3K/dy3K.
In addition, we examined skeletal muscles in the pre-necrosis period of dy3K/dy3K. In dy3K/dy3K, massive necrosis occurs suddenly on postnatal day 10. We found the activation of caspase-12 on postnatal day 9. Accordingly, the endoplasmic reticulum (ER) stress-induced apoptosis seems to take place just before the necrosis of muscle fibers in dy3K/dy3K.

  • Research Products

    (12 results)

All 2004 2003 2002

All Journal Article (12 results)

  • [Journal Article] Ultrastructural detection of DNA fragmentation in myonuclei of fatal reducing body myopathy2004

    • Author(s)
      Ikezoe k et al.
    • Journal Title

      Acta Neuropathol (Berl) 107

      Pages: 439-442

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] HTLV-1-associated myelopathy/tropical spastic paraparesis accompanied with psoriasis2004

    • Author(s)
      Watanabe A et al.
    • Journal Title

      J Neurol Sci 221

      Pages: 95-97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A case of dermato-fasciitis : amyopathic dermatomyositis associated with fasciitis2004

    • Author(s)
      Tsuruta Y et al.
    • Journal Title

      Clin Rheumatol 23

      Pages: 160-162

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 成人期に増悪した良性先天型ネマリンミオパチーで、生検筋に縁取り空胞と筋電図上神経原性所見のみを呈した1例2004

    • Author(s)
      池添浩二 他
    • Journal Title

      臨床神経 44

      Pages: 450-453

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Ultrastructural detection of DNA fragmentation in myonuclei of fatal reducing body myopathy.2004

    • Author(s)
      Ikezoe K, et al.
    • Journal Title

      Acta Neuropathol (Berl) 107(5)

      Pages: 439-442

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A case of dermato-fasciitis : amyopathic dermatomyositis associated with fasciitis.2004

    • Author(s)
      Tsuruta Y, et al.
    • Journal Title

      Clin Rheumatol 23(2)

      Pages: 160-162

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] HTLV-1-associated myelopathy/tropical spastic pararesis accompanied with psoriasis.2004

    • Author(s)
      Watanabe A, et al.
    • Journal Title

      J Neurol Sci 221(1-2)

      Pages: 95-97

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dysferlin expression in tubular aggregates : their possible relationship to endoplasmic stress2003

    • Author(s)
      Ikezoe k et al.
    • Journal Title

      Acta Neuropathol (Berl) 105

      Pages: 603-609

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dysferlin expression in tubular aggregates: their possible relationship to endoplasmic reticulum stress.2003

    • Author(s)
      Ikezoe K, et al.
    • Journal Title

      Acta Neuropathol (Berl) 105(6)

      Pages: 603-609

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Apoptosis is suspended in muscle of mitochondrial encephalomyopathies2002

    • Author(s)
      Ikezoe K et al.
    • Journal Title

      Acta Neuropathol (Berl) 103

      Pages: 530-540

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Apoptosis is suspended in muscle of mitochondrial encephalomyopathies.2002

    • Author(s)
      Ikezoe K et al.
    • Journal Title

      Acta Neuropathol (Berl) 103(6)

      Pages: 531-540

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increased membrane permeability in early postnatal period of laminin alpha2 chain-null mice, dy^<3K>/dy^<3K>.2002

    • Author(s)
      Nakagawa M et al.
    • Journal Title

      Acta Myologica XX(2)

      Pages: 167-173

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2006-07-11  

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