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2004 Fiscal Year Final Research Report Summary

Dynamic conical conformal radiotherapy using a C-arm mounted accelerator and its treatment planning software

Research Project

Project/Area Number 14570839
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAGAWA Keiichi  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80188896)

Co-Investigator(Kenkyū-buntansha) ONOGI Yuzo  The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (90233593)
TERAHARA Atsuro  The University of Toho, Radiology, Assistant Professor, 医学部附属病院, 助教授 (80237007)
TAGO Masao  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50282520)
NAKAMURA Naoki  The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40359625)
NAKANISHI Tetsuya  Mitsubishi Electric Corporation, Chief Researcher, 主任研究員
Project Period (FY) 2002 – 2004
KeywordsC-arm linac / conformal radiotherapy / Dyconic CRT / 3D-CRT / RTP
Research Abstract

The aim of the study was to improve dose distribution with rotational conformal radiotherapy (RCRT) using a C-arm mounted accelerator. The linac head was designed to move along the C-arm with a maximum angle of 60 degrees (from a vertical position toward the gantry). Simultaneous rotation of the gantry creates a dynamic conical irradiation technique. Dynamic conical conformal radiation therapy (Dyconic CRT) was developed by combining the technique with continuous motion of multi-leaf collimator (MLC). Dose distributions were measured in phantoms using film densitometry and compared with conventional RCRT. Dose distributions in actual radiation therapy patients are also presented. Dyconic CRT actualized precise non-coplanar beam entry without table rotation. In addition, a specialized treatment planning software for Dyconic CRT was completed on a commercially available RTP computer. The measurements showed that three-dimensionally proportional dose gradient was achieved with Dyconic CRT, when compared to that with conventional RCRT. Dose in homogeneity in the sagittal direction with Dyconic CRT was compensated by use of 30-degree wedge. Drawback of RCRT in dose distribution was overcome with the present technique.

  • Research Products

    (11 results)

All 2004 2003

All Journal Article (10 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K他
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.2004

    • Author(s)
      Satoru Iwase, Keichi Nakagawa 他
    • Journal Title

      The European Cytokine Network 15

      Pages: 312-316

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2004

    • Author(s)
      Tago M, Terahara A, Nakagawa K, 他
    • Journal Title

      J Neurosurg (Suppl)102

      Pages: 171-174

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004

    • Author(s)
      Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H, Suzuki N
    • Journal Title

      Int J Oncol 25

      Pages: 461-468

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.2004

    • Author(s)
      Satoru Iwase, Tadashi Murakami, Yuichiro Saito, Keichi Nakagawa.
    • Journal Title

      The European Cytokine Network 15

      Pages: 312-316

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gamma knife radiosurgery for hemangioblastomas.2004

    • Author(s)
      Tago M, Terahara A, Shin M, Maruyama K, Kurita H, Nakagawa K, Ohtomo K
    • Journal Title

      J Neurosurg (Suppl) 102

      Pages: 171-174

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intercomparison of Dose Distribution between Gamma Knife and C-arm-mounted LINAC2003

    • Author(s)
      Keiichi Nakagawa, Masao Tago 他
    • Journal Title

      Radiation Medicine vol 21, no4

      Pages: 178-182

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dynamic Conical Conformal Radiotherapy sing A C-Arm Mounted Accelerator : Dose Distribution And Clinical Application.2003

    • Author(s)
      Keiichi Nakagawa, Yukimasa Aoki 他
    • Journal Title

      International Journal of Raciation Oncology, Biology, Physics 56

      Pages: 287-295

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Intercomparison of Dose Distribution between Gamma Knife and C-arm-mounted LINAC2003

    • Author(s)
      Keiichi Nakagawa, Masao Tago, Kouji Shibata, Naoki Nakamura, Hideomi Yamashita, Atsuro Terahara, Kuni Ohtomo
    • Journal Title

      Radiation Medicine. vol 21, no4

      Pages: 178-182

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dynamic Conical Conformal Radiotherapy sing A C-Arm Mounted Accelerator : Dose Distribution And Clinical Application.2003

    • Author(s)
      Keiichi Nakagawa, Yukimasa Aoki, Masao Tago, Kuni Ohtomo
    • Journal Title

      International Journal of Radiation Oncology, Biology, Physics 56

      Pages: 287-295

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 特許2004

    • Inventor(s)
      中川 恵一
    • Industrial Property Number
      特願2004-356062
    • Filing Date
      2004-12-08
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2006-07-11  

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