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2005 Fiscal Year Final Research Report Summary

Three-dimensional analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography-cross sectional and longitudinal studies-

Research Project

Project/Area Number 14570852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionShiga University of Medical Science

Principal Investigator

TAKADA Masahiko  Shiga University of Medical Science, Assistant professor, 医学部, 講師 (10187974)

Co-Investigator(Kenkyū-buntansha) IMAI Shinji  Shiga University of Medical Science, Associate professor, 医学部, 助教授 (90283556)
Project Period (FY) 2002 – 2005
Keywordsosteoporosis / trabecular pattern / 3 D-structural analysis / multi-detector row CT / bone mineral density
Research Abstract

We developed a system to perform three-dimensional(3D) analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography(MDCT). The purpos was to evaluate whether 3D structural parameters can evaluate fragility of bone. We studied 20 women with no vertebral fractures(67±8 years old) and 27 women with vertebral fractures(74±7 years old). They underwent lumbar examinations by MDCT and dual x-ray absorptiometry(DXA). The' following 3D parameters were calculated ; trabecular bone volume fraction(BV/TV), trabecular thickness(Tb.Th), trabecular number(Tb.N), trabecular separation(Tb.Sp), trabecular bone pattern factor(TBPf), structure model index(SMI), and Fractal dimension(FD). Correlation between structural parameters and BMD was evaluated by linear regression analysis, and discrimination between women with and without vertebral fractures was evaluated by student t' test. The BMD was significantly correlated with the values of BV/TV,.Tb.Sp, TBPf, SMI and FD with correlation coefficients of 0.30,0.32,-0.46,-0.44 and 0.36,respectively. The values of TBPf, SMI and FD significantly differed between the two groups with t-values of 2.6,3.2,and 2.4,respectively, but the L3 BMD did not differ. The results suggested that trabecular bone structure correlated with BMD and that the trabecular bone structural analysis could evaluate bone fragility cross-sectionlay. We evaluated the same subjects londitudinaly for four years, but these parameters did not change significantly.

  • Research Products

    (2 results)

All 2004

All Journal Article (2 results)

  • [Journal Article] 平成15年度文部科学省科学研究補助金採択研究課題の成果 「臨床用CTによるヒト腰椎インビボ3次元骨梁構造解析-横断的検討と縦断的検討2004

    • Author(s)
      高田政彦, 菊地克久, 今井晋二, 村田喜代史
    • Journal Title

      INNERVISION 19・7

      Pages: 50

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Three-dimensional analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography-cross sectional and longitudinal studies-2004

    • Author(s)
      Takada M, kikuchi K, Imai S, Murata K
    • Journal Title

      INNERVISION Vol 19, No 7

      Pages: 50

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2008-05-27  

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