2005 Fiscal Year Final Research Report Summary
Three-dimensional analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography-cross sectional and longitudinal studies-
| Project/Area Number |
14570852
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
TAKADA Masahiko Shiga University of Medical Science, Assistant professor, 医学部, 講師 (10187974)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IMAI Shinji Shiga University of Medical Science, Associate professor, 医学部, 助教授 (90283556)
|
|---|
| Project Period (FY) |
2002 – 2005
|
| Keywords | osteoporosis / trabecular pattern / 3 D-structural analysis / multi-detector row CT / bone mineral density |
|---|
| Research Abstract |
We developed a system to perform three-dimensional(3D) analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography(MDCT). The purpos was to evaluate whether 3D structural parameters can evaluate fragility of bone. We studied 20 women with no vertebral fractures(67±8 years old) and 27 women with vertebral fractures(74±7 years old). They underwent lumbar examinations by MDCT and dual x-ray absorptiometry(DXA). The' following 3D parameters were calculated ; trabecular bone volume fraction(BV/TV), trabecular thickness(Tb.Th), trabecular number(Tb.N), trabecular separation(Tb.Sp), trabecular bone pattern factor(TBPf), structure model index(SMI), and Fractal dimension(FD). Correlation between structural parameters and BMD was evaluated by linear regression analysis, and discrimination between women with and without vertebral fractures was evaluated by student t' test. The BMD was significantly correlated with the values of BV/TV,.Tb.Sp, TBPf, SMI and FD with correlation coefficients of 0.30,0.32,-0.46,-0.44 and 0.36,respectively. The values of TBPf, SMI and FD significantly differed between the two groups with t-values of 2.6,3.2,and 2.4,respectively, but the L3 BMD did not differ. The results suggested that trabecular bone structure correlated with BMD and that the trabecular bone structural analysis could evaluate bone fragility cross-sectionlay. We evaluated the same subjects londitudinaly for four years, but these parameters did not change significantly.
|
