2003 Fiscal Year Final Research Report Summary
Damages and protection of brain function caused by ionizing radiation
| Project/Area Number |
14570895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
ANDO Koichi National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Researcher, 重粒子医科学センター・粒子線治療生物研究グループ, 研究員 (00159526)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Sentaro National Institute of Radiological Sciences, Research Center for Radiation Safety, Researcher, 放射線安全研究センター, 研究員 (60163268)
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| Project Period (FY) |
2002 – 2003
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| Keywords | carbon ions / memory / learning / pathology / acetylcholine / hippocampus / melatonin / radiation |
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| Research Abstract |
Local brain irradiation was conducted for C57 B1 mice with HIMAC carbon ions (290 MeV/u, Spread-out-Brag Peak of 5-mm width ). Three months after a single dose of 30 Gy irradiation, irradiated mice were tested for acquisition of a place task using a Morris water maze. Mice showed apparent dysfunction in both learning and short-term memory. Histopathology of the irradiated brain showed a remarkable reduction (39-49%) of neural cells at CA1 through CA3 regions of hippocampus. Second, we irradiated rats with 1.5 Gy X rays at embryonic sage of E15. After born and grown, the prenatally irradiated rats showed a significant deficit in learning ability. A group of mice showing severe deficit in learning ability also developed heterotropic cells at CA1 through CA3 regions of hippocampus. Specific bindings of acetylcholine receptor was also reduced at hippocampus with ectopia. These results strongly suggest that radiation-induced impairment of learning/memory function would be primarily due to anormality of hippocampus such as reduction of neural cells and appearance of ectopia. The anormality is likely to interfere with neural signaling. Third, we found that administration of pseudouridine and melatonin, i.e., beer components, protected mice bone marrow and gut damages induced by whole body photon irradiation.
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[Publications] S.Koike, K.Ando, C.Oohira, T.Fukawa, R.lee, N.Takai, M.Monobe, Y.Furusawa, M.Aoki, S.Yamada, W.Shimizu, K.Nojima, H.Majima: "Relative biological effectiveness of 290 MeV/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma."J.Radiat.Res.. 42. 247-255 (2002)
Description
「研究成果報告書概要(欧文)」より
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