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2006 Fiscal Year Final Research Report Summary

Mechanical dynamics of focal adhesions of vascular endothelial cells using nano-imaging

Research Project

Project/Area Number 15086203
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

SATO Masaaki  Tohoku University, Department of Bioengineering and Robotics, Professor (30111371)

Co-Investigator(Kenkyū-buntansha) OHASHI Toshiro  Tohoku University, Department of Bioengineering and Robotics, Associate Professor (30270812)
DEGUCHI Shinji  Okayama University, Department of Energy Systems Engineering, Research Associate (30379713)
SAKAMOTO Naoya  Tohoku University, Department of Bioengineering and Robotics, Research Associate (20361115)
Project Period (FY) 2003 – 2006
KeywordsFocal adhesions / Actin filaments / Gene transfection / Flow exposure / Stretching / Micromachining / Mechanotransduction
Research Abstract

The goal of this project is to study dynamics of FAT domain in focal adhesions and associated actin filaments in order to understand remodeling process of adherent cells in response to external mechanical stimuli. In particular, newly developed experimental techniques here include a time-course observation of dynamics of FAT domain and actin filaments under application of fluid flow and a stretching system using an elastic membrane with nonuniform surface structure. First, we have developed an experimental system which enables to observe dynamics of cells using RFP-conjugated FAT-domain vector and GFP-conjugated actin vector. The result showed that actin filament structure was reconfigured in a close association with appearance/disappearance of FAT domain. Second, PDMS membrane with an array of micropillars has been fabricated by using soft lithography technique to locally apply stretching between focal adhesions. Endothelial cells formed focal adhesion complexes at peripheries of the top of the micropillars and developed stress fibers, thick actin bundles, perpendicular to the direction of stretch. Finally, we have developed a micro-tensile tester to measure mechanical properties of stress fibers, which would be critical for understanding of intracellular stress transfer. Tensile tests were, for the first time, carried out on stress fibers chemically isolated from endothelial cells, providing a load-displacement relationship. It was found that the load-displacement curve was nonlinear with high extensibility. We have successfully studied important roles of cytoskeletons and focal adhesions of mechanically stimulated cells in intracellular force transmission mechanism.

  • Research Products

    (168 results)

All 2007 2006 2005 2004 2003

All Journal Article (40 results) (of which Peer Reviewed: 24 results) Presentation (124 results) Book (4 results)

  • [Journal Article] Microelastic mapping of living endothelial cells exposed to shear stress in relation to three-dimensional distribution of actin filaments2007

    • Author(s)
      M. Sato
    • Journal Title

      Acta Biomaterialia 3

      Pages: 311-319

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effects of frequency of pulsatile flow on morphology and integrin expression of vascular endothelial cells2007

    • Author(s)
      K. Ito
    • Journal Title

      Health Care and Technology 15

      Pages: 91-101

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells2007

    • Author(s)
      T. Ohashi
    • Journal Title

      Journal of Biomechanics 40

      Pages: 2399-2405

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Nonuniform strain of substrate induces local development of stress fibers in endothelial cells under uniaxial cyclic stretching2007

    • Author(s)
      T. Ohashi
    • Journal Title

      Clinical Hemorheology and Microcirculation 37

      Pages: 37-46

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of mechanical environment of focal adhesions on remodeling of endothelial cells subjected to cyclic stretch using microstructured substrate2007

    • Author(s)
      N. Sakamoto
    • Journal Title

      Journal of Robotics and Mechatronics 19

      Pages: 557-564

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of mechanical environment of focal adhesionson remodeling of endothelial cells subjected to cyclic stretch using microstructured substrate2007

    • Author(s)
      N. Sakamoto
    • Journal Title

      Journal of Robotics and Mechatronics 19(5)

      Pages: 557-564

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2007

    • Author(s)
      Hiroshi, Wada
    • Journal Title

      World Scientific, Singapore 4

      Pages: 60-71

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of fluid shear stress on migration of vascular smooth muscle cells in cocultured model2006

    • Author(s)
      N. Sakamoto
    • Journal Title

      Annals of Biomedical Engineering 34

      Pages: 408-415

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Tensile properties of single stress fibers isolated from cultured vascular smooth muscle cells2006

    • Author(s)
      S. Deguchi
    • Journal Title

      Journal of Biomechanics 39

      Pages: 2603-2610

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Nitric oxide production and smooth muscle cell phenotype of endothelial cell-smooth muscle cell cocultured model2006

    • Author(s)
      N. Sakamoto
    • Journal Title

      Journal of Biomechanical Science and Engineering 1

      Pages: 224-233

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of actin filament distribution on tensile properties of smooth muscle cells obtained from rat thoracic aortas2006

    • Author(s)
      K. Nagayama
    • Journal Title

      Journal of Biomechanics 39

      Pages: 293-301

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Adhesive force of human hepatoma HepG2 cells to human umbilical vein endothelial cells and role of E-Selectin by micropipette2006

    • Author(s)
      G B. Song
    • Journal Title

      Molecular and Cellular Biomechanics 3

      Pages: 61-68

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] HUVECの形態およびVEカドヘリン発現に与える静水圧の影響2006

    • Author(s)
      大橋俊朗
    • Journal Title

      日本生体医工学会誌 44

      Pages: 454-459

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2006

    • Author(s)
      Hiroshi Wada
    • Journal Title

      World Scientific, Singapore 2

      Pages: 62-71

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Adhesive force of human hepatoma, HepG2 cells to human umbilical vein endothelial cells and role of E-Selectin by micropipette2006

    • Author(s)
      G. B. Song
    • Journal Title

      Molecular and Cellular Biomechanics 3(2)

      Pages: 61-68

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Morphology and Expression of VE-Cadherin of HUVEC Exposed to Hydrostatic Pressure(In Japanese)2006

    • Author(s)
      T. Ohashi
    • Journal Title

      Transactions of the Japanese Society for Medical and Biological Engineering 44(3)

      Pages: 454-459

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Flow-induced hardening of endothelial nucleus as an intracellular stress-bearingorganelle2005

    • Author(s)
      S. Deguchi
    • Journal Title

      Journal of Biomechanics 38

      Pages: 1751-1759

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Newly designed tensile test system for in vitro measurement of mechanical properties of cytoskeletal filaments2005

    • Author(s)
      S. Deguchi
    • Journal Title

      JSME International Journal, Series C 48

      Pages: 396-402

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Evaluation of tension in actin bundle of endothelial cells based on preexisting strain and tensile properties measurements2005

    • Author(s)
      S. Deguchi
    • Journal Title

      Molecular and Cellular Biomechanics 2

      Pages: 125-134

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Intracellular stress transmission through actin stress fiber network in adherent vascular cells2005

    • Author(s)
      S. Deguchi
    • Journal Title

      Molecular and Cellular Biomechanics 2

      Pages: 205-216

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Remodeling of vascular endothelial cells exposed to fluid shear stress : Experimental and numerical approach2005

    • Author(s)
      T. Ohashi
    • Journal Title

      Fluid Dynamics Research 37

      Pages: 40-59

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Biorheological views of endothelial cell responses to mechanical stimuli2005

    • Author(s)
      M. Sato
    • Journal Title

      Biorheology 42

      Pages: 421-441

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Flow-induced hardening of endothelial nucleus as an intracellular stress-bearing organelle2005

    • Author(s)
      S. Deguchi
    • Journal Title

      Journal of Biomechanics 38

      Pages: 1751-1759

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2005

    • Author(s)
      Hiroshi Wada
    • Journal Title

      World Scientific, Singapore 1

      Pages: 65-74

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 細包の力学特性計測のためのレーザ顕微鏡組込み型原子間力顕微鏡(AFM)システムの開発2004

    • Author(s)
      長山和亮
    • Journal Title

      日本機械学会論文集C編 70

      Pages: 736-742

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of shear stress on permeability of vascular endothelial monolayer cocultured with smooth muscle cells2004

    • Author(s)
      N. Sakamoto
    • Journal Title

      JSME International Journal, Series C 47

      Pages: 992-999

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 構造最適化による流れ負荷内皮細胞の有限要素法解析2004

    • Author(s)
      大橋俊朗
    • Journal Title

      日本機械学会論文集A編 70

      Pages: 1262-1268

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Development of Newly Designed Atomic Force Microscope System for Measuring of Mechanical Properties of Cells(In Japanese)2004

    • Author(s)
      K. Nagayama
    • Journal Title

      Transactions of JSME, Series C 70

      Pages: 736-742

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Finite element analysis for sheared vascular endothelial cells using structural optimization method (In Japanese)2004

    • Author(s)
      T. Ohashi
    • Journal Title

      Transactions of JSME, Series A 70

      Pages: 1262-1268

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Handbook of Structural Engineering2004

    • Author(s)
      G. Yagawa
    • Journal Title

      Maruzen, Tokyo

      Pages: 799-802

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Elongation and random orientation of bovine endothelial cells in response tohydrostatic pressure : comparison with response to shear stress2003

    • Author(s)
      Y. Sugaya
    • Journal Title

      JSME Int. J., Ser. C 46・4

      Pages: 1248-1255

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 培養動脈組織片の初期ひずみ状態が内皮細胞の形態および細胞骨格構造に及ぼす影響2003

    • Author(s)
      佐藤正明
    • Journal Title

      日本機械学会論文集A編 69

      Pages: 30-36

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 流れ刺激を受ける内皮細胞内骨格構造の実時間挙動観察2003

    • Author(s)
      大橋俊朗
    • Journal Title

      日本バイオレオロジー学会誌 17

      Pages: 24-28

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 力学的刺激に対する血管内皮細胞の応答現象2003

    • Author(s)
      大橋俊朗
    • Journal Title

      生物物理 43・3

      Pages: 136-141

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Oxygen tension modulates Ca^<2+>response to flow stimulus in endothelial cells exposed to hydrostatic pressure2003

    • Author(s)
      T. Ohashi
    • Journal Title

      Technology and Health Care 11

      Pages: 263-274

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Elongation and random orientation of bovine endothelial cells in response tohydrostatic pressure : comparison with response to shear stress2003

    • Author(s)
      Y. Sugaya
    • Journal Title

      JSME International Journal, Series C 46

      Pages: 1248-1255

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of Initial Stretch Conditions of Cultured Aortic Wall Segment on Shape and Cytoskeletal Structure of Endothelial Cells(In Japanese)2003

    • Author(s)
      M. Sato
    • Journal Title

      Transactions of JSME, Series A 69

      Pages: 30-36

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Real-time Observations of Actin Filament Dynamics in Cultured Endothelial Cells Exposed to Fluid Flow (In Japanese)2003

    • Author(s)
      T. Ohashi
    • Journal Title

      Journal of Japanese Society of Biorheology 17

      Pages: 24-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Remodeling of vascular endothelial cells exposed to mechanical stimuli(In Japanese)2003

    • Author(s)
      T. Ohashi
    • Journal Title

      Seibutsu Butsuri 43

      Pages: 136-141

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Oxygen tension modulates Ca^<2+> response to flow stimulus in endothelial cells exposed to hydrostatic pressure2003

    • Author(s)
      T. Ohashi
    • Journal Title

      Technology and Health Care 11

      Pages: 263-274

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 細胞間接着部位への局所力学刺激負荷に伴う血管内皮細胞の細胞骨格構造変化2007

    • Author(s)
      植木洋輔
    • Organizer
      日本機械学会第19回バイオエンジニアリング講演会
    • Place of Presentation
      宮城
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] FRAPを用いた力学刺激負荷平滑筋細胞のアクチンダイナミクスの観察2007

    • Author(s)
      伊藤一志
    • Organizer
      日本機械学会第19回バイオエンジニアリング講演会
    • Place of Presentation
      宮城
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 牽引力測定による平滑筋細胞内力学バランスの推定2007

    • Author(s)
      中村昌司
    • Organizer
      日本機械学会第19回バイオエンジニアリング講演会
    • Place of Presentation
      宮城
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Strain rate-dependent tensile properties of single stress fibers isolated from smooth muscle cells2007

    • Author(s)
      Tsubasa Matsui
    • Organizer
      9th International Symposium of Future Medical Engineering Based on Bio-nanotechnology
    • Place of Presentation
      宮城
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Change in cytoskeletal structure of vascular endothelial cells induced by mechanical stimulation at intercellular junctions (In Japanese)2007

    • Author(s)
      Y. Ueki
    • Organizer
      The 19th Bioengineering Conference, 2006 Annual Meeting of BE D/JSME
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Actin dynamics in smooth muscle cells in response to mechanical stimulation using FRAP technique(In Japanese)2007

    • Author(s)
      K. Ito
    • Organizer
      The 19th Bioengineering Conference, 2006 Annual Meeting of BE D/JSME
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Estimation of stress balance in smooth muscle cells by traction force measurements(In Japanese)2007

    • Author(s)
      S. Nakamura
    • Organizer
      The 19th Bioengineering Conference, 2006 Annual Meeting of BE D/JSME
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Strain rate-dependent tensile properties of single stress fibers isolated from smooth muscle cells2007

    • Author(s)
      T. Matsui
    • Organizer
      9th International Symposium of Future Medical Engineering Based on Bio-nanotechnology
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2007-01-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effects of Hydrostatic Pressure on Morphology of Cultured Bovine Aortic Endothelial Cells2006

    • Author(s)
      Masaaki Sato
    • Organizer
      Fifth East Asian Biophysics Symposium &Forty-Fourth Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      沖縄
    • Year and Date
      2006-11-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of Hydrostatic Pressure on Morphology of Cultured Bovine Aortic Endothelial Cells2006

    • Author(s)
      M. Sato
    • Organizer
      Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2006-11-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Control of Cell Morphology and Measurement of Traction Forces of Smooth Muscle Cells Using Microfabricated Substrates2006

    • Author(s)
      Toshiro Ohashi
    • Organizer
      The 2006 International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      名古屋
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Control of Cell Morphology and Measurement of Traction Forces of Smooth Muscle Cells Using Microfabricated Substrates2006

    • Author(s)
      T. Ohashi
    • Organizer
      2006 International Symposium on Micro-Nano Mechatronics and Human Science(MHS2006)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2006-11-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Transendothelial migration of leukocytes in cocultured vessel model exposed to shear stress2006

    • Author(s)
      Naoya Sakamoto
    • Organizer
      2006 Annual Fall Meeting of BMES
    • Place of Presentation
      イリノイ(アメリカ)
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Transendothelial migration of leukocytes in cocultured vessel model exposed to shear stress2006

    • Author(s)
      N. Sakamoto
    • Organizer
      Annual Fall Meeting of BMES
    • Place of Presentation
      Illinois, USA
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] マトリックスデバイスを用いた平滑筋細胞の形態制御と牽引力測定2006

    • Author(s)
      大橋俊朗
    • Organizer
      日本機械学会2006年度年次大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 単離ストレスファイバの引張特性と局所ひずみ分布2006

    • Author(s)
      松井 翼
    • Organizer
      日本機械学会2006年度年次大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Control of Cell Morphology and Measurement of Traction Forces of Smooth Muscle Cells Using Microfabricated Devices(In Japanese)2006

    • Author(s)
      T. Ohashi
    • Organizer
      Mechanical Engineering Congress, 2006 Japan
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Tensile Properties and Local Strain Distribution of Isolated Stress Fibers(In Japanese)2006

    • Author(s)
      T. Matsui
    • Organizer
      Mechanical Engineering Congress, 2006 Japan
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Intracellular force balance in actin stress fiber network2006

    • Author(s)
      Shinji Deguchi
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Biomechanical Properties and Roles of Stress Fibers in Mechanotransduction2006

    • Author(s)
      Masaaki Sato
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Endothelial Biomechanics : Focusing on the Dynamic Behavior of Cytoskeletal Structure2006

    • Author(s)
      Masaaki Sato
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical Role of Cytoskeletal Structures in Traction Forces of Smooth Muscle Cells Using Different Configuration of Micropillars2006

    • Author(s)
      Toshiro Ohashi
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Intracellular force balance in actin stress fiber network2006

    • Author(s)
      S. Deguchi
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Biomechanical Properties and Roles of Stress Fibers in Mechanotransduction2006

    • Author(s)
      M. Sato
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Endothelial Biomechanics : Focusing on the Dynamic Behavior of Cytoskeletal Structure2006

    • Author(s)
      M. Sato
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical Role of Cytoskeletal Structures in Traction Forces of Smooth Muscle Cells Using Different Configuration of Micropillars2006

    • Author(s)
      T. Ohashi
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Morphological Changes of Cultured Bovine Aortic Endothelial Cells by Exposure to Hydrostatic Pressure2006

    • Author(s)
      Masaaki Sato
    • Organizer
      International Symposium on Cardiovascular Biology First Meeting on Endothelial Cell In Health and Hypertension
    • Place of Presentation
      プラハ(チェロ)
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Morphological Changes of Cultured Bovine Aortic Endothelial Cells by Exposure to Hydrostatic Pressure2006

    • Author(s)
      M. Sato
    • Organizer
      International Symposium On Cardiovascular Biology First Meeting On Endothelial Cell In Health And Hypertension
    • Place of Presentation
      Praha, Czech Republic
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] マイクロピラーを用いた平滑筋細胞の牽引力計測と細胞骨格の果たす役割2006

    • Author(s)
      大橋俊朗
    • Organizer
      第45回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 単離したストレスファイバの引張特性に与えるひずみ速度の影響2006

    • Author(s)
      松井 翼
    • Organizer
      第45回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurement of traction forces in smooth muscle cells using micropillar and role of cytoskeleton(In Japanese)2006

    • Author(s)
      T. Ohashi
    • Organizer
      The 45th Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Tensile Properties of Isolated Stress Fibers Affected by Strain Rate(In Japanese)2006

    • Author(s)
      T. Matsui
    • Organizer
      The 45th Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical Properties of Isolated Internal Organs of Vascular Cells2006

    • Author(s)
      Masaaki Sato
    • Organizer
      TMS 2006
    • Place of Presentation
      テキサス(アメリカ)
    • Year and Date
      2006-03-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical Properties of Isolated Internal Organs of Vascular Cells2006

    • Author(s)
      M. Sato
    • Organizer
      TMS 2006
    • Place of Presentation
      Texas, USA
    • Year and Date
      2006-03-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 微細加工マトリックスデバイスを用いた平滑筋細胞の接着院と増殖能の測定2006

    • Author(s)
      山崎 純一
    • Organizer
      日本機械学会第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 平滑筋細胞の牽引力に及ぼす骨格構造の力学的役割2006

    • Author(s)
      大橋俊朗
    • Organizer
      日本機械学会第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] ひずみ速度が単離ストレスファイバの引張特性に与える影響2006

    • Author(s)
      松井翼
    • Organizer
      日本機械学会第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurement of adhesion properties and proliferation of smooth muscle cell using microfabricated matrix device(In Japanese)2006

    • Author(s)
      J. Yamazaki
    • Organizer
      The 18th Bioengineering Conference, 2005 Annual Meeting of BE D/JSME
    • Place of Presentation
      Niigata, Japan
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical role of cytoskeletal structures in traction forces in smooth muscle cells(In Japanese)2006

    • Author(s)
      T. Ohashi
    • Organizer
      The 18th Bioengineering Conference, 2005 Annual Meeting of BE D/JSME
    • Place of Presentation
      Niigata, Japan
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The Effect of Strain Rate on Tensile Properties of Isolated Stress Fibers(In Japanese)2006

    • Author(s)
      T. Matsui
    • Organizer
      The 18th Bioengineering Conference, 2005 Annual Meeting of BE D/JSME
    • Place of Presentation
      Niigata, Japan
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Contributions of cytoskeletal structures to traction forces generated by smooth muscle cells using microfabricated substrate2005

    • Author(s)
      Toshiro Ohashi
    • Organizer
      The 12th International Conference on Biomedical Engineering
    • Place of Presentation
      シンガポール
    • Year and Date
      2005-12-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Multilayered Phenomena of Cultured Bovine Aortic Endothelial Cells by Exposure to Hydrostatic Pressure2005

    • Author(s)
      Masaaki Sato
    • Organizer
      The 12th International Conference on Biomedical Engineering
    • Place of Presentation
      シンガポール
    • Year and Date
      2005-12-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Contributions of cytoskeletal structures to traction forces generated by smooth muscle cells using microfabricated substrate2005

    • Author(s)
      T. Ohashi
    • Organizer
      The 12th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Year and Date
      2005-12-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Multilayered Phenomena of Cultured Bovine Aortic Endothelial Cells by Exposure to Hydrostatic Pressure2005

    • Author(s)
      M. Sato
    • Organizer
      The 12th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Year and Date
      2005-12-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Frequency of Shear Stress Modulates Integrin Expression in Endothelial Cells2005

    • Author(s)
      Kazushi Ito
    • Organizer
      The 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology
    • Place of Presentation
      宮城
    • Year and Date
      2005-11-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Frequency of Shear Stress Modulates Integrin Expression in Endothelial Cells2005

    • Author(s)
      K. Ito
    • Organizer
      The 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2005-11-21
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 拍動流が血管内皮細胞のインテグリン発現に及ぼす影響2005

    • Author(s)
      伊藤一志
    • Organizer
      日本機械学会第16回バイオフロンティア講演会
    • Place of Presentation
      滋賀
    • Year and Date
      2005-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effect of Pulsatile Flow on Integrin Expression of Endothelial Cells (In Japanese)2005

    • Author(s)
      K. Ito
    • Organizer
      The 16th JSME Conference on Frontiers in Bioengineering
    • Place of Presentation
      Shiga, Japan
    • Year and Date
      2005-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 流れ負荷内皮細胞における骨格構造と焦点接着斑の果たす役割2005

    • Author(s)
      大橋俊朗
    • Organizer
      日本機械学会2005年度年次大会
    • Place of Presentation
      東京
    • Year and Date
      2005-09-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Cytoskeleton and Focal Adhesion in Sheared Endothelial Cells(In Japanese)2005

    • Author(s)
      T. Ohashi
    • Organizer
      Mechanical Engineering Congress, 2005 Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2005-09-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effects of Hydrostatic Pressure on Endothelial Cell Responses2005

    • Author(s)
      Masaaki Sato
    • Organizer
      The 2nd Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      京都
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The role of cytoskeletal structures in traction forces in smooth muscle cells2005

    • Author(s)
      Toshiro Ohashi
    • Organizer
      The 2nd Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      京都
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of Hydrostatic Pressure on Endothelial Cell Responses2005

    • Author(s)
      M. Sato
    • Organizer
      The 2nd Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] The role of cytoskeletal structures in traction forces in smooth muscle cells2005

    • Author(s)
      T. Ohashi
    • Organizer
      The 2nd Japan-Switzerland Workshopon Biomechanics
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2005-09-12
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Tensile properties of single stress fibers characterized by in vitro manipulation2005

    • Author(s)
      Shinji Deguchi
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      重慶(中国)
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Subcellular distribution of traction forces of smooth muscle cells using micropatterned substrates2005

    • Author(s)
      Toshiro Ohashi
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      重慶(中国)
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Biorheological Views for Endothelial Responses to Mechanical Stimuli2005

    • Author(s)
      Masaaki Sato
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      重慶(中国)
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Tensile properties of single stress fibers characterized by in vitro manipulation2005

    • Author(s)
      S. Deguchi
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      Chongquin, China
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Subcellular distribution of traction forces of smooth muscle cells using micropatterned substrates2005

    • Author(s)
      T. Ohashi
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      Chongquin, China
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Biorheological Views for Endothelial Responses to Mechanical Stimuli2005

    • Author(s)
      M. Sato
    • Organizer
      The 12th International Congress of Biorheology
    • Place of Presentation
      Chongquin, China
    • Year and Date
      2005-05-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Endothelial Cells and Blood Flow Dynamics2005

    • Author(s)
      Masaaki Sato
    • Organizer
      第82回日本生理学会
    • Place of Presentation
      宮城
    • Year and Date
      2005-05-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Endothelial Cells and Blood Flow Dynamics2005

    • Author(s)
      M. Sato
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2005-05-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 培養内皮細胞の形態変化に及ぼすせん断応力と静水圧の相乗作用2005

    • Author(s)
      大橋俊朗
    • Organizer
      第44回日本生体医工学会大会
    • Place of Presentation
      茨城
    • Year and Date
      2005-04-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of both fluid shear stress and hydrostatic pressure on morphology of vascular endothelial cells (In Japanese)2005

    • Author(s)
      T. Ohashi
    • Organizer
      The 44th Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Ibaraki, Japan
    • Year and Date
      2005-04-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical properties of isolated stress fibers and nuclei to understand mechanical responses of endothelial cells2005

    • Author(s)
      Masaaki Sato
    • Organizer
      6th Asian・Pacific Conference on Biomedical Engineering
    • Place of Presentation
      茨城
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Synergistic effects of hydrostatic pressure and fluid shear stress on morphology of cultured endothelial cells2005

    • Author(s)
      Toshiro Ohashi
    • Organizer
      6th Asian-Pacific Conference on Biomedical Engineering
    • Place of Presentation
      茨城
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical properties of isolated stress fibers and nuclei to understand mechanical responses of endothelial cells2005

    • Author(s)
      M. Sato
    • Organizer
      6th Asian-Pacific Conference on Biomedical Engineering
    • Place of Presentation
      Ibaraki, Japan
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Synergistic effects of hydrostatic pressure and fluid shear stress on morphology of cultured endothelial cells2005

    • Author(s)
      T. Ohashi
    • Organizer
      6th Asian-Pacific Conference on Biomedical Engineering
    • Place of Presentation
      Ibaraki, Japan
    • Year and Date
      2005-04-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 流れ負荷培養内皮細胞の骨格構造と焦点接着斑の経時観察2005

    • Author(s)
      熊谷良治
    • Organizer
      日本機械学会第17回バイオエンジニアリング講演会
    • Place of Presentation
      愛知
    • Year and Date
      2005-01-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 流れの拍動周期が培養内皮細胞の接着既に及ぼす影響2005

    • Author(s)
      伊藤一志
    • Organizer
      日本機械学会第17回バイオエンジニアリング講演会
    • Place of Presentation
      愛知
    • Year and Date
      2005-01-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Temporal Observation of Changes in Cytoskeletal Structure and Focal Adhesions in Cultured Endothelial Cells Exposed to Fluid Flow(In Japanese)2005

    • Author(s)
      Y. Kumagai
    • Organizer
      The 17th Bioengineering Conference, 2004 Annual Meeting of BE D/JSME
    • Place of Presentation
      Aichi, Japan
    • Year and Date
      2005-01-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effect of Periods of Pulsatile Flow on Cell-Matrix Adhesion of Cultured Endothelial Cells(In Japanese)2005

    • Author(s)
      K. Ito
    • Organizer
      The 17th Bioengineering Conference, 2004 Annual Meeting of BE D/JSME
    • Place of Presentation
      Aichi, Japan
    • Year and Date
      2005-01-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Morphology and Expression of VE-cadherin of Bovine Endothelial Cells Exposed to Hydrostatic Pressure2004

    • Author(s)
      Yoshiaki Sugaya
    • Organizer
      2004 BMES Annual Fall Meeting
    • Place of Presentation
      ペンシルバニア(アメリカ)
    • Year and Date
      2004-10-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical Properties of a Single Stress Fiber Isolated from Cultured Smooth Muscle Cells2004

    • Author(s)
      Masaaki Sato
    • Organizer
      2004 BMES Annual Fall Meeting
    • Place of Presentation
      ペンシルバニア(アメリカ)
    • Year and Date
      2004-10-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Morphology and Expression of VE-cadherin of Bovine Endothelial Cells Exposed to Hydrostatic Pressure2004

    • Author(s)
      Y. Sugaya
    • Organizer
      2004 BMES Annual Fall Meeting
    • Place of Presentation
      Pennsylvania, USA
    • Year and Date
      2004-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical Properties of a Single Stress Fiber Isolated from Cultured Smooth Muscle Cells2004

    • Author(s)
      M. Sato
    • Organizer
      2004 BMES Annual Fall Meeting
    • Place of Presentation
      Pennsylvania, USA
    • Year and Date
      2004-10-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ストレスファイバの力学特性に基づいた接着細胞の力学構造モデル2004

    • Author(s)
      出口真次
    • Organizer
      日本機械学会2004年度年次大会
    • Place of Presentation
      北海道
    • Year and Date
      2004-09-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 静水圧による培養内皮細胞の形態変化とカドヘリンの発現2004

    • Author(s)
      菅谷嘉晃
    • Organizer
      日本機械学会2004年度年次大会
    • Place of Presentation
      北海道
    • Year and Date
      2004-09-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical model for adherent cells based on mechanical properties of stress fibers(In Japanese)2004

    • Author(s)
      S. Deguchi
    • Organizer
      Mechanical Engineering Congress, 2004 Japan
    • Place of Presentation
      Hokkaido, Japan
    • Year and Date
      2004-09-06
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Morphological responses and VE-cadherin expression of cultured endothelial cells exposed to hydrostatic pressure (In Japanese)2004

    • Author(s)
      Y. Sugaya
    • Organizer
      Mechanical Engineering Congress, 2004 Japan
    • Place of Presentation
      Hokkaido, Japan
    • Year and Date
      2004-09-06
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Morphological Responses of Aortic Endothelial Cells to Physiological Hydrostatic Pressure2004

    • Author(s)
      Toshiro Ohashi
    • Organizer
      14th European Society of Biomechanics Conference
    • Place of Presentation
      スヘルトーヘンボス(オランダ)
    • Year and Date
      2004-07-04
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Morphological Responses of Aortic Endothelial Cells to Physiological Hydrostatic Pressure2004

    • Author(s)
      T. Ohashi
    • Organizer
      14th European Society of Biomechanics Conference(ESB2004)
    • Place of Presentation
      s-Hertogenbosch, The Netherlands
    • Year and Date
      2004-07-04
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 静水圧に対する培養内皮細胞の形態的変化とその評価方法2004

    • Author(s)
      坂元尚哉
    • Organizer
      第43回日本エム・イー学会大会
    • Place of Presentation
      石川
    • Year and Date
      2004-05-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 平滑筋細胞の初期ひずみの計測2004

    • Author(s)
      出口真次
    • Organizer
      第43回日本エム・イー学会大会
    • Place of Presentation
      石川
    • Year and Date
      2004-05-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Evaluation of morphological change in cultured endothelial cells exposed to hydrostatic pressure(In Japanese)2004

    • Author(s)
      N. Sakamoto
    • Organizer
      The 43rd Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Ishikawa, Japan
    • Year and Date
      2004-05-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Measurement of preexisting strain of stress fibers in smooth muscle cells(In Japanese)2004

    • Author(s)
      S. Deguchi
    • Organizer
      The 43rd Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Ishikawa, Japan
    • Year and Date
      2004-05-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Significance of pretension of single stress fibers in living smooth muscle cells2004

    • Author(s)
      Shinji Deguchi
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      大阪
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurement of mechanical properties of subcellular components in adherent cells2004

    • Author(s)
      Shinji Deguchi
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      大阪
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effect of Actin Filament on Tensile Properties of Rat Aortic Smooth Muscle Cells2004

    • Author(s)
      Takeo Matsumoto
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      大阪
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Significance of pretension of single stress fibers in living smooth muscle cells2004

    • Author(s)
      S. Deguchi
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Measurement of mechanical properties of subcellular components in adherent cells2004

    • Author(s)
      S. Deguchi
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effect of Actin Filament on Tensile Properties of Rat Aortic Smooth Muscle Cells2004

    • Author(s)
      T. Matsumoto
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2004-03-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effect of nonuniform strain of substrate on cytoskeletal structure of endothelial cell2004

    • Author(s)
      Toshiro Ohashi
    • Organizer
      Workshop on Biomedical Engineering and Biomaterials 2004
    • Place of Presentation
      福岡
    • Year and Date
      2004-01-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effect of nonuniform strain of substrate on cytoskeletal structure of endothelial cell2004

    • Author(s)
      T. Ohashi
    • Organizer
      Workshop on Biomedical Engineering and Biomaterials 2004
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2004-01-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 細胞骨格と核の力学特性の計測2004

    • Author(s)
      出口真次
    • Organizer
      日本機械学会第16回バイオエンジニアリング講演会
    • Place of Presentation
      福岡
    • Year and Date
      2004-01-22
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurement of mechanical properties of cytoskeleton and nucleus(In Japanese)2004

    • Author(s)
      S. Deguchi
    • Organizer
      The 16th Bioengineering Conference, 2003 Annual Meeting of BE D/JSME
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2004-01-22
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Shear Stress to Endothelial Cells Controls Migration of Cocultured Smooth Muscle Cells2003

    • Author(s)
      Masaaki Sato
    • Organizer
      国際シンポジウム第1回循環フィジオーム
    • Place of Presentation
      岡山
    • Year and Date
      2003-12-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Shear Stress to Endothelial Cells Controls Migration of Cocultured Smooth Muscle Cells2003

    • Author(s)
      M. Sato
    • Organizer
      International Symposium Cardiovascular Physiom
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2003-12-05
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Remodeling of endothelial nucleus in response to fluid flow2003

    • Author(s)
      Shinji Deguchi
    • Organizer
      The First us National Symposium on Frontiers inBiomechanics
    • Place of Presentation
      テネシー(アメリカ)
    • Year and Date
      2003-09-30
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Remodeling of endothelial nucleus in response to fluid flow2003

    • Author(s)
      S. Deguchi
    • Organizer
      The First US National Symposium on Frontiers in Biomechanics, Forging a New Biomechanics in the Era of Modern Biology
    • Place of Presentation
      Tennessee, USA
    • Year and Date
      2003-09-30
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ストレスファイバの粘弾性特性の計測2003

    • Author(s)
      出口真次
    • Organizer
      日本機械学会第14回バイオフロンティア講演会
    • Place of Presentation
      宮城
    • Year and Date
      2003-09-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 静水圧が培養内皮細胞の形態に与える影響2003

    • Author(s)
      菅谷嘉晃
    • Organizer
      日本機械学会第14回バイオフロンティア講演会
    • Place of Presentation
      宮城
    • Year and Date
      2003-09-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurements of viscoelastic properties of single stress fibers(In Japanese)2003

    • Author(s)
      S. Deguchi
    • Organizer
      The 14th JSME Conference on Frontiers in Bioengineering
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2003-09-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Effect of hydrostatic pressure on morphology of cultured endothelial cells(In Japanese)2003

    • Author(s)
      Y. Sugaya
    • Organizer
      The 14th JSME Conference on Frontiers in Bioengineering
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2003-09-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] A possible mechanism by which mechanical stimuli produce polarity in single endothelial cells2003

    • Author(s)
      Shinji Deguchi
    • Organizer
      The 2nd International Symposium on Future Medical Engineering based on Bio-nanotechnology
    • Place of Presentation
      宮城
    • Year and Date
      2003-09-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A possible mechanism by which mechanical stimuli produce polarity in single endothelial cells2003

    • Author(s)
      S. Deguchi
    • Organizer
      The 2nd International Symposium on Future Medical Engineering based on Bio-nanotechnology
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2003-09-16
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dynamic Behavior of Focal Adhesion-Associated Proteins of Cultured Endothelial CeUs in Shear Flow Conditions2003

    • Author(s)
      Masaaki Sato
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2003-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical properties differ between single stress fibers and actin filaments2003

    • Author(s)
      Shinji Deguchi
    • Organizer
      World congress on medical physics and biomedical engineering 2003
    • Place of Presentation
      シドニー(オーストラリア)
    • Year and Date
      2003-08-24
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Dynamic Behavior of Focal Adhesion-Associated Proteins of Cultured Endothelial Cells in Shear Flow Conditions2003

    • Author(s)
      M. Sato
    • Organizer
      World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2003-08-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Mechanical properties differ between single stress fibers and actin filaments2003

    • Author(s)
      S. Deguchi
    • Organizer
      World congress on medical physics and biomedical engineering 2003
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2003-08-24
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 細胞核の力学特性の計測と微細構造の観察2003

    • Author(s)
      出口真次
    • Organizer
      日本機械学会2003年度年次大会
    • Place of Presentation
      徳島
    • Year and Date
      2003-08-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] せん断応力負荷内皮細胞における焦点接着斑とアクチンフィラメントの動的挙動2003

    • Author(s)
      大橋俊朗
    • Organizer
      日本機械学会2003年度年次大会
    • Place of Presentation
      徳島
    • Year and Date
      2003-08-06
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Measurement of elastic modulus of cell nuclei and observation of their microstructure(In Japanese)2003

    • Author(s)
      S. Deguchi
    • Organizer
      Mechanical Engineering Congress, 2003 Japan
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2003-08-06
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Dynamic behavior of focal adhesions and associated actin filaments of sheared endothelial cells(In Japanese)2003

    • Author(s)
      T. Ohashi
    • Organizer
      Mechanical Engineering Congress, 2003 Japan
    • Place of Presentation
      Tokushima, Japan
    • Year and Date
      2003-08-06
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Rupture Properties and Histological Observations of Human Thoracic Aortic Aneurysms2003

    • Author(s)
      Toshiro Ohashi
    • Organizer
      Second International Conference on Cardiovacular Medicine and Science
    • Place of Presentation
      ワシントン(米国)
    • Year and Date
      2003-07-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Rupture Properties and Histological Observations of Human Thoracic Aortic Aneurysms2003

    • Author(s)
      T. Ohashi
    • Organizer
      Second International Conference on Cardiovacular Medicine and Science
    • Place of Presentation
      Washington, USA
    • Year and Date
      2003-07-23
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Single stress fibers isolated from vascular smooth muscle cells possess surprisingly high extensibility2003

    • Author(s)
      Shinji Deguchi
    • Organizer
      2003 Summer Bioengineering Conference
    • Place of Presentation
      フロリダ(アメリカ)
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Temporal observation of dynamic process of focal adhesion-associated proteins in sheared endothelial cells2003

    • Author(s)
      Toshiro Ohashi
    • Organizer
      2003 Summer Bioengineering Conference
    • Place of Presentation
      フロリダ(アメリカ)
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Endothelial cells exposed to fluid shear stress regulate migration of cocultured smooth muscle cells2003

    • Author(s)
      Naoya Sakamoto
    • Organizer
      2003 Summer Bioengineering Congress
    • Place of Presentation
      フロリダ(アメリカ)
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Single stress fibers isolated from vascular smooth muscle cells possess surprisingly high extensibility2003

    • Author(s)
      S. Deguchi
    • Organizer
      2003 Summer Bioengineering Conference
    • Place of Presentation
      Florida, USA
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Temporal observation of dynamic process of focal adhesion-associated proteins in sheared endothelial cells2003

    • Author(s)
      T. Ohashi
    • Organizer
      2003 Summer Bioengineering Conference
    • Place of Presentation
      Florida, USA
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Endothelial cells exposed to fluid shear stress regulate migration of cocultured smooth muscle cells2003

    • Author(s)
      N. Sakamoto
    • Organizer
      2003 Summer Bioengineering Congress
    • Place of Presentation
      Florida, USA
    • Year and Date
      2003-06-25
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 平滑筋細胞から単離したストレスファイバの引張試験2003

    • Author(s)
      出口真次
    • Organizer
      第42回日本エム・イー学会大会
    • Place of Presentation
      北海道
    • Year and Date
      2003-06-03
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Tensile test of single stress fibers isolated fromvascular smooth muscle cells(In Japanese)2003

    • Author(s)
      S. Deguchi
    • Organizer
      The 42nd Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Hokkaido, Japan
    • Year and Date
      2003-06-03
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. IV2007

    • Author(s)
      Hiroshi Wada
    • Total Pages
      60-71
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. II2006

    • Author(s)
      Hiroshi Wada
    • Total Pages
      62-71
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. I2005

    • Author(s)
      Hiroshi Wada
    • Total Pages
      65-74
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 構造工学ハンドブック(13章1・2 細胞構造)2004

    • Author(s)
      矢川元基
    • Total Pages
      799-802
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-06-09  

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