2004 Fiscal Year Final Research Report Summary
The experimental study of the induction of tissue regeneration filling in the thoracic cavity using the bioabsorbable materials slowly releasing growth factors.
| Project/Area Number |
15390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
YOKOMISE Hiroyasu Kagawa University, Faculty of Medicine, MD.Ph.D., Professor, 医学部, 教授 (80231728)
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| Co-Investigator(Kenkyū-buntansha) |
岡本 卓 国立大学法人香川大学, 医学部附属病院, 助手 (20314932)
YAMAMOTO Yasumichi Kagawa University, Faculty of Medicine, MD.Ph.D., Lecturer, 医学部附属病院, 講師 (50314927)
CHENG-LONG Huang Kagawa University, Faculty of Medicine, MD.Ph.D., Associate Professor, 医学部, 助教授 (10271511)
TABATA Yasuhiko Kyoto University, Institute for Frontier Medical Science, MD.Ph.D., Professor, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2003 – 2004
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| Keywords | gelatin micro-spheres / lactic acid and caprolactone copolymer cube / granulation / thoracic cavity / basic fibroblast growth factor / rabbits / pneumonectomy / inflammatory cells |
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| Research Abstract |
We investigated whether the lactic acid and caprolactone copolymer cube (PLA-C) induce granulation in the thoracic cavity and evaluated the efficiency of sprinkled basic fibroblast growth factor slow releasing gelatin micro-spheres (FGF-GMS).
Six rabbits underwent pneumonectomy as the control. The PLA-Cs were placed in the post pneumonectomy cavity in the other 4 as the PLA-C group. The PLA-Cs were placed in the cavity with sprinkling FGF-GMS in the last 6 as the PLA-C+FGF group. We examined the excised materials in each group at 1, 2 and 3 months, respectively.
In the control, there was no growth of granulation. The fibrous collagen layer covered on the every implanted PLA-Cs. Induction of granulation was limited inside of the PLA-C, started from peripheral area of the PLA-C and continued at 3 months in the PLA-C group but decayed in the PLA-C+FGF groups. The inflammatory cells invaded into the PLA-C along the septum of the PLA-C. FGF-GMS conducted the fibroblasts invasion into the pores and accelerated the thickening of the covering fibrous layer.
The granulation could be controlled by the size of the PLA-C. The degradation periods of PLA-C might be controlled by the size of the PLA-C, its pore size and additional FGF-GMS.
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Research Products
(12 results)
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[Journal Article] Cartilage regeneration using slow release of bone morphogenetic protein (BMP)-2 from a gelatin sponge to treat experimental canine tracheomalacia : a preliminary report.2003
Author(s)
Taku Okamoto, Yasumichi Yamamoto, Masashi Gotoh, Dage Liu, Minoru Kihara, Kotaro Kameyama, Eiichi Hayashi, Kenji Nakamura, Akira Yamauchi, Cheng-long Huang, Hiroyasu Yokomise, Masaya Yamamoto, Tatsuo Nakamura, Yasuhiko Shimizu, Yasuhiko Tabata
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Journal Title
Description
「研究成果報告書概要(欧文)」より
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