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2005 Fiscal Year Final Research Report Summary

Physiological characteristics of pikas as the animal adapted to extreme environments of "cold and high-altitude"

Research Project

Project/Area Number 15406007
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionChukyo University (2005)
Aichi Medical University (2003-2004)

Principal Investigator

MATSUMOTO Takaaki  Chukyo University, School of Health and Sport Sciences, Professor, 体育学部, 教授 (60199875)

Co-Investigator(Kenkyū-buntansha) SAKAI Akio  Shinshu University, School of Medicine, Associate Professor, 大学院医学研究科, 助教授 (70020758)
SAITO Muneo  Central Institute for Experimental Animals, Head ofLaboratory Animals Center, 実験動物研究部, 室長 (50167417)
MATSUZAKI Tetsuya  Central Institute for Experimental Animals, Head of Laboratory Animals Center, 実験動物研究部, 室長 (30167647)
YAHATA Takehiro  Nayoro City College, School of Nursing, Professor, 看護学科, 教授 (60041828)
Project Period (FY) 2003 – 2005
Keywordspika / cold adaptation / high-altitude adaptation / circadian rhythm / brown adipose tissue / UCP1 / China / Mongolia
Research Abstract

1) Recording the body temperature rhythm of wild pikas by field telemetry method showed clearly that a pika is essentially diurnal both in summer and in winter. 2) Whole year monitoring of burrow and outside temperatures showed that the burrow (an underground tunnel network or the space between the rocks) play an important role as a shelter not only against for natural enemies but also for summer heat and winter cold. 3) Monitoring the body temperature of the wild pika in winter suggested the un-hibernating nature of pikas strongly. 4) Generally, cardiac weight (right/left heart weight ratio) increased by cold in addition to low oxygen in winter, but it did not increase in winter compared with the value of a summer in the wild pika, as same as in the other animals living under ground. 5) The oxygen consumption of the pika became the minimum value at 20 ℃, and was lower than that of the rat at the temperatures between 0 and 30 ℃. 6) As a result of comparing the heat production ability of the brown adipose tissue (BAT) of wild pikas with rats, it was clarified that BAT play an important role in cold-tolerance in pikas. 7) In the pikas reared in the warm, BAT was whitish like white adipose tissue and was composed of a large lipid droplet in electro-microscopic observation. In the pikas exposed to acute cold, most cytoplasm was seen in the small cells. BAT uncoupling protein (UCP1) mRNA was identified in all pikas, and the intensity of UCP1mRNA become strong by acute cold exposure. As a result of the partial analysis of the base sequence of UCP1mRNA, pika UCP1 showed the highest homology with rabbit UCP1.

  • Research Products

    (34 results)

All 2006 2005 2004 2003

All Journal Article (34 results)

  • [Journal Article] Winter body temperature in the black-lipped pikas, Ochotona curzoniae, in their natural habitat.2006

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 56・S

      Pages: S103

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 寒冷・高地適応動物ナキウサギの環境適応策 : 概日リズムの使い分け2006

    • Author(s)
      松本孝朗, 他
    • Journal Title

      第2回環境生理プレコングレスプログラム抄録集

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 中国青海省「多巴高地トレーニングセンサー」視察報告2006

    • Author(s)
      松本孝朗
    • Journal Title

      中京大学体育学論叢 44・1

      Pages: 61-64

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ナキウサギ褐色脂肪組織における脱共役タンパクの発現2006

    • Author(s)
      八幡剛浩, 他
    • Journal Title

      日本生気象学会雑誌 43・3

      Pages: S80

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Winter body temperature in the black-lipped pikas, Ochotona curzoniae, in their natural habitat.2006

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 56

      Pages: S103

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ナキウサギの行動性体温調節性環境適応 : 温度的シェルターとしての巣穴の役割2005

    • Author(s)
      松本孝朗, 他
    • Journal Title

      日本生気象学会雑誌 42・3

      Pages: S47

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Behavioral adaptation to the climate in the pikas. -Role of the burrow/space under the talus as a thermal shelter-2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      17th International Congress of Biometeorology Program and Abstract

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Physiology and ecology of the pika (Ochotona) high altitude- and cold-adapted animal.2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 55・S

      Pages: S65

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparison of cardiopulmonary response to endogenous nitric oxide inhibition in pigs inhabited at three levels of altitude.2005

    • Author(s)
      Ruan Zonghai, et al.
    • Journal Title

      Eur J Appl Physiol 94・1-2

      Pages: 93-96

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cardiopulmonary adaptation to high-altitude in mammals.2005

    • Author(s)
      Sakai A, et al.
    • Journal Title

      Jpn J Physiol 55・S

      Pages: S65

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effect of light cycle on the circadian rhythm in the Daurian pika (Ochotona Daurica).2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 55・S

      Pages: S199

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Behavioral adaptation to the climate in the pikas.2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      -Role of the burrow/space under the talus as a thermal shelter-17th International Congress of Biometeorology Program and Abstract

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparison of cardiopulmonary response to endogenous nitric oxide inhibition in pigs inhabited at three levels of altitude.2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 55

      Pages: S65

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparison of cardiopulmonary response to endogenous nitric oxide inhibition in pigs inhabited at three levels of altitude.2005

    • Author(s)
      Ruan Zonghai, et al.
    • Journal Title

      Eur J Appl Physiol 94

      Pages: 93-96

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cardiopulmonary adaptation to high-altitude in mammals.2005

    • Author(s)
      Sakai A, et al.
    • Journal Title

      Jpn J Physiol 55

      Pages: S65

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of light cycle on the circadian rhythm in the Daurian pika (Ochotona Daurica)2005

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 55

      Pages: S199

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Contribution of nitric oxide to adaptation of Tibetan sheep to high altitude.2004

    • Author(s)
      Tomonobu Koizumi, et al.
    • Journal Title

      Respir Physiol Neurobiol. 140・2

      Pages: 189-196

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Circadian body temperature rhythm in the wild black-lipped pikas (Ochotona curzoniae) in their natural habitat in Qinghai, China.2004

    • Author(s)
      Takaaki Matsumoto, et al.
    • Journal Title

      1st Integrated Symposium the Physiology and Pharmacology of Thermal Biology and Temperature Regulation Abstract

      Pages: 61

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep.2004

    • Author(s)
      Ruan Zonghai, et al.
    • Journal Title

      Eur J Appl Physiol. 93・1-2

      Pages: 190-195

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Blunted effect of the Kv channel inhibitor on pulmonary circulation in Tibetan sheep : a model for studying hypoxia and pulmonary artery pressure regulation.2004

    • Author(s)
      Takeshi Ishizaki, et al.
    • Journal Title

      Respirology. 9・1-

      Pages: 125-129

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The Change in peripheral sweating mechanisms of the tropical Malaysian who stays in Japan.2004

    • Author(s)
      Jeong-Beom Lee, et al.
    • Journal Title

      J. Thermal Biology 29

      Pages: 743-747

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Contribution of nitric oxide to adaptation of Tibetan sheep to high altitude.2004

    • Author(s)
      Tomonobu Koizumi, et al.
    • Journal Title

      Respir Physiol Neurobiol. 140

      Pages: 189-196

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Circadian body temperature rhythm in the wild black-lipped pikas (Ochotona curzuniae) in their natural habitat in Qinghai, China.2004

    • Author(s)
      Takaaki Matsumoto, et al.
    • Journal Title

      1st Integrated Symposium the Physiology and Pharmacology of Thermal Biology and Temperature Regulation Abstract. P61

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep.2004

    • Author(s)
      Ruan Zonghai, et al.
    • Journal Title

      Eur J Appl Physiol. 93

      Pages: 190-195

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Blunted effect of the Kv channel inhibitor on pulmonary circulation in Tibetan sheep : a model for studying hypoxia and pulmonary artery pressure regulation.2004

    • Author(s)
      Takeshi Ishizaki, et al.
    • Journal Title

      Respirology. 9

      Pages: 125-129

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Change in peripheral sweating mechanisms of the tropical Malaysian who stays in Japan. J.2004

    • Author(s)
      Jeong-Beom Lee, et al.
    • Journal Title

      Thermal Biology. 29

      Pages: 743-747

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Occurrence of the spinal reflex due to skin pressure in sudomotor and cutaneous vasoconstrictor nerve system of humans.2003

    • Author(s)
      Okagawa T et al.
    • Journal Title

      Autonom Neurosci : Basic and Clinical 105

      Pages: 62-70

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cardiopulmonary hemodynamics of blue-sheep, Pseudois nayaur, as high-altitude adapted mammals.2003

    • Author(s)
      Sakai A, Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 53・5

      Pages: 377-384

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] カプサイシンによる発汗反応について2003

    • Author(s)
      犬飼洋子 他
    • Journal Title

      発汗学 10・1

      Pages: 21-24

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 熱傷後に暑熱耐性の低下と多汗を生じた症例の温熱生理学的検討2003

    • Author(s)
      松本孝朗 他
    • Journal Title

      発汗学 10・2

      Pages: 42-46

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 人工炭酸泉(1000ppm)全身浴時の体温、皮膚血流量、発汗量および主観的感覚に及ぼす水温の影響2003

    • Author(s)
      西村直記 他
    • Journal Title

      炭酸泉誌 4・1

      Pages: 49-56

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Circadian body temperature rhythm in the wild black-lipped pikas (Ochotona curzoniae) in their natural habitat in Qinghai, China2003

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol 53・S

      Pages: S305

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cardiopulmonary hemodynamics of blue-sheep, Pseudois nayaur, as high-altitude adapted mammals.2003

    • Author(s)
      Sakai A, Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol. 53

      Pages: 377-384

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Circadian body temperature rhythm in the wild black-lipped pikas (Ochotona curzuniae) in their natural habitat in Qinghai, China.2003

    • Author(s)
      Matsumoto T, et al.
    • Journal Title

      Jpn J Physiol. 53

      Pages: S305

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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