2005 Fiscal Year Final Research Report Summary
Crystallization mechanism and control technology of polymorphous molecular complex crystals
| Project/Area Number |
15560655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | University of Hyogo (2005)
Hiroshima University (2003-2004) |
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Principal Investigator |
KITAMURA Mitsutaka University of Hyogo, Department of Mechanical and System Engineering, Professor, 大学院・工学研究科, 教授 (60127644)
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| Project Period (FY) |
2003 – 2005
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| Keywords | molecular complex / polymorph / crystallization / dissolution / transformation / release control |
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| Research Abstract |
The release control of biocide was studied using clathrate compound which was formed with the host of Tetrakis (4-hydroxyphenyl) ethane and the guest isothiazoline (Biocide). It, was cleared that in the release process of the biocide the new stable form of the clathrate crystals precipitate. The release process of the biocide is combined with the dissolution of the initial clathrate and the crystallization of the solvent-clathrate. Further more it cleared that the concentration of the biocide was influenced by solution compositions, temperature and stirring rate.
The crystallization of polymorphous pharmaceutical (BPT) was also investigated using anti-crystallization method. BPT was crystallized by adding water as ant solvent in methanol solutions of BPT. It was clarified that the crystallization and transformation behaviors were influenced by the adding rate of water, initial concentration and temperature. The transformation rate was influenced by solution compositions and temperatures. These results indicate that the crystallization mechanism of polymorphs is very complicated and many influential factors are included. On this account, for the control of the polymorphs in crystallizations the combination of several key controlling factors is important.
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