2005 Fiscal Year Final Research Report Summary
Is the disturbed early phase insulin response prescribed by the genetical role?
| Project/Area Number |
15590491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MIZUNO Akira The University of Tokushima, Medical and Dental Hospital, Instructor, 医学部・歯学部附属病院, 助手 (80219641)
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| Co-Investigator(Kenkyū-buntansha) |
NOMA Yoshihiko The University of Tokushima, Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (10218349)
ARAI Hidekazu The University of Tokushima, Graduate School Institute of Health Biosciences, Instructor, 大学院・ヘルスバイオサイエンス研究部, 助手 (60325256)
TSUKAGUCHI Hiroyasu The University of Tokushima, Graduate School Institute of Health Biosciences, Instructor, 大学院・ヘルスバイオサイエンス研究部, 助手 (60335792)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Portal glucose sensor / Clamp-CPR-OGL method / Early phase insulin response / Obese subject / Impaired glucose tolerance |
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| Research Abstract |
lesion but not in pancreas and cephalic lesion. Previous study would suggest that hindrance in early phase insulin response (EPIS) is strongly related to onset and worsen type 2 diabetes mellitus. Measurement of EPIS using Clamp-OGL-CPR method was underwent in over 70 patients with obese and impaired glucose tolerance, although it had been done in only 30 subjects without obesity and normal glucose tolerance. We analyzed the EIS during Clamp-OGL-CPR method in normal subject who were divided into two groups, one group with diabetic diathesis and the other group without that, after the measurement of insulinogenic index during 75g OGTT. The results suggested that responsiveness of EPIS correlated with insulinogenic index and the diathesis of type 2 DM did not relate to disturbance in EPIS. After these studies, we started genetic markers concerning hindrances in EPIS, which reported to be existing in intestine and portal vein. We evaluated the polymorphism of glucokinase (GK) gene, although no significant difference was not determined between the two groups. Now we have been searching the diadetic gene, which will be related to portal glucose sensor.
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