A novel vaccines based on dendritic/tumor fusion cells

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 15590693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The Jikei University School of Medicine
• Principal Investigator: KOIDO Shigeo The Jikei University School of Medicine, Lecturer, 医学部, 講師 (70266617)
• Project Period (FY): 2003 – 2005
• Keywords: dendritic cells / colorectal cancer / fusion cells / immunotherapy / CTL / tumor associated antigens / IFN-γ / tetramer

Research Abstract

1.Human metastatic colorectal cancer cells expressing the CEA and/or MUC1 may represent a potential partner for the creation of DC/tumor fusion cells targeting induction of antigen-specific CTL responses.
2.The fusion of allogeneic colorectal carcinoma cell line and autologous dendritic cells could have potential applicability to the field of antitumor immunotherapy through the cross-priming against shared tumor antigens.

Research Products

• [Journal Article] Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells. (2005)
  • Author(s): Koido S, Hara E, Homma S Torii A, Toyama Y, Kawahara H, Watanabe M, Yanaga K, Fujise K, Tajiri H, Gong J, Toda G.
  • Journal Title: Clin Cancer Res. 11・21 Pages: 7891-7900
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Assessment of fusion cells from patient-derived ovarian carcinoma cells and dendritic cells as a vaccine for clinical use. (2005)
  • Author(s): Koido S, Nikrui N, Ohana M, Xia J, Tanaka Y, Liu C, Ourfee JK, Lerner A, Gong J
  • Journal Title: Gynecol Oncol. 99・2 Pages: 462-471
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells. (2005)
  • Author(s): Koido S, Hara E, Torii A, Homma S, Toyama Y, Kawahara E, Ogawa M, Watanabe M, Yanaga K, Fujise K, Gong J, Toda G.
  • Journal Title: Int J Cancer. 117・4 Pages: 587-595
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of impaired antitumor immunity by fusion of MHC class II-deficient dendritic cells with tumor cells. (2005)
  • Author(s): Tanaka Y*, Koido S, * Ohana M, Liu C, Gong J. (* equally contributed)
  • Journal Title: J Immunol. 174・3 Pages: 1274-1280
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells. (2005)
  • Author(s): Koido S, Hara E, Homma S, Torii A, Toyama Y, Kawahara H, Watanabe M, Yanaga K, Fujise K, Tajiri H, Gong J, Toda G.
  • Journal Title: Clin Cancer Res. 11 Pages: 7891-7900
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Assessment of fusion cells from patient-derived ovarian carcinoma cells and dendritic cells as a vaccine for clinical use. (2005)
  • Author(s): Koido S, Nikrui N, Ohana M, Xia J, Tanaka Y, Liu C, Durfee JK, Lerner A, Gong J.
  • Journal Title: Gynecol Oncol. 99 Pages: 462-471
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of antigen-specific CD4- and CD8-mediated T-cell responses by fusions of autologous dendritic cells and metastatic colorectal cancer cells. (2005)
  • Author(s): Koido S, Hara E, Torii A, Homma S, Toyama Y, Kawahara H, Ogawa M, Watanabe M, Yanaga K, Fujise K, Gong J, Toda G.
  • Journal Title: Int J Cancer. 117 Pages: 587-589
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of impaired antitumor immunity by fusion of MHC class II-deficient dendritic cells with tumor cells. (2005)
  • Author(s): Tanaka Y^*, Koido S^*, Ohana M, Liu C, Gong J.(^* equally contributed)
  • Journal Title: J Immunol. 174 Pages: 1274-1280
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dendritic cells fused with human cancer cells : morphology antigen expression, and T cell stimulation (2004)
  • Author(s): Koido S, Ohana M, Liu C, Nikrui N, Durfee J, Lerner A, Gong J.
  • Journal Title: Clin Immunol. 113・3 Pages: 261-269
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts (2004)
  • Author(s): D, Jonas A, Galinacy I, DeAngelo D, Avigan D, Kufe D, Stone R.
  • Journal Title: Leuk Res. 2004 Dec;1303-12. 28・12 Pages: 1303-1312
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. (2004)
  • Author(s): Tanaka Y*, Koido S*, Xia J, Ohana M, Liuc, Cote GM, Sawyer DB, Calderwood S, Gong J. (* equally contributed)
  • Journal Title: J Immunol. 172・12 Pages: 7848-7858
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dendritic cells fused with human cancer cells : morphology, antigen expression, and T cell stimulation. (2004)
  • Author(s): Koido S, Ohana M, Liu C, Nikrui N, Durfee J, Lerner A, Gong J.
  • Journal Title: Clin Immunol. 113 Pages: 261-269
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of anti-leukemic cytotoxic T lymphocytes by fusion of patient-derived dendritic cells with autologous myeloblasts. (2004)
  • Author(s): Gong J, Koido S, Kato Y, Tanaka Y, Chen D, Jonas A, Galinsky I, DeAngelo D, Avigan D, Kufe D, Stone R.
  • Journal Title: Leuk Res. Dec;28 Pages: 1303-1312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. (2004)
  • Author(s): Tanaka Y^*, Koido S^*, Xia J, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. (^* equally contributed)
  • Journal Title: J Immunol. 172 Pages: 7848-7858
  • Description: 「研究成果報告書概要(欧文)」より