2004 Fiscal Year Final Research Report Summary
THE SEARCH FOR CANDIDATE GENES OF SCHIZOPHRENIA IN SERIAL ANALYSIS OF GENE EXPRESION (SAGE)
| Project/Area Number |
15591209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
ITO Chihiro TOHOKU UNIVERSITY, HOSPITAL, LECTURER, 病院, 講師 (60292330)
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| Co-Investigator(Kenkyū-buntansha) |
KURAMASU Atsuro TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, RESEARCH ASSOCIATE, 大学院・医学系研究科, 助手 (90302091)
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| Project Period (FY) |
2003 – 2004
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| Keywords | PHENCYCLIDINE / SCHIZOPHRENIA / SAGE / POLYMORPHISM |
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| Research Abstract |
Phencyclidine (PCP)-injected animals are considered models of both drug dependence and schizophrenia. To identify genes associated with these diseases, we used serial analysis of gene expression to determine gene expression profiles in rodent cerebral cortices isolated 1 hour after intraperitoneal injection of saline or PCP (10 mg/kg). We identified 215 PCP-reactive tags and assembled data for significantly up-or down-regulated genes.
Transthyretin (TTR) up-regulated in PCP library, is a kind of thyroid hormone-binding plasma proteins. DNA analysis of the 70 Japanese schizophrenic subjects revealed that the incidence of the polymorphisms of transthyretin was not significantly different in the 101 Japanese control subjects. But, our SAGE data could contain unknown genes related to schizophrenia and/or drug-related disorders.
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