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2004 Fiscal Year Final Research Report Summary

Monitoring of CD15s Ag in Clinical Renal Tx and xenogereic model.

Research Project

Project/Area Number 15591717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTokyo Women's Medical University

Principal Investigator

ISHIDA Hideki  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (60246543)

Co-Investigator(Kenkyū-buntansha) TANABE Kazunari  TWMU, Dept of Urology, Assist Professor, 医学部, 助教授 (80188359)
MIYAMOTO Naoshi  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (50366332)
SHIRAKAWA Hiroki  TWMU, Dept of Urology, Clinical fellow, 医学部, 助手 (60263539)
TOMA Hiroshi  TWMU, Dept of Urology, Professor, 医学部, 教授 (90075549)
Project Period (FY) 2003 – 2004
KeywordsCD15s antigen / blood type incompatible / Renal Transplantation / Xonotransplantation / immuno suppressive regimen
Research Abstract

Renal transplantation across the blood barrier is a unique model for investigating the humoral response to different carbohydrate antigens. However, in such a renal transplantation, the characteristics of B cells as well as of the antibodies produced by B cells are less well defined.
In the present study we investigated B cell subsets, i.e., the CD5(+) B-1 and CD5(-) B-2 subsets, by flow cytometric analysis, and their subclasses of antibody, by ELISA, in patients who had undergone renal transplantation across the blood barrier. The subjects consisted of five recipients with good function (group 1) and five recipients with graft loss (group 2) accompanied by antibody-titer elevation after ABO-incompatible renal transplantation.
The B-cell population analysis revealed that CD5(+) B-1 cells temporarily increased in all patients in both groups soon after transplantation, and that CD5(-) B-2 cells significantly increased one month after transplantation only in group 2. The antibody subclasses analysis showed mild elevation of IgG2 and IgM in group 1 as opposed to remarked elevation of IgG2,IgM and IgG1 in group 2.

  • Research Products

    (12 results)

All 2005 2004 2003 2002

All Journal Article (12 results)

  • [Journal Article] Evaluation of Flow PRA in renal transplant recipients2005

    • Author(s)
      石田英樹
    • Journal Title

      Transplant International 18(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Evaluation of Flow PRA in renal transplant recipients.2005

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Int 18(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Efficacy of IgM anti-blood type Ab by ELISA2004

    • Author(s)
      石田英樹
    • Journal Title

      Transplant Proceeding 36

      Pages: 2178-2181

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hepatitis C virus decreases in patients with HF therapy2004

    • Author(s)
      石田英樹
    • Journal Title

      Artificial Organs 28

      Pages: 316-318

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Organ donation problems in Japan2004

    • Author(s)
      石田英樹
    • Journal Title

      Saudi Kidney Dis Transplant 15

      Pages: 125-128

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Efficacy of IgM anti-blood type antibody monitoring by ELISA after renal transplantation2004

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Proc 36

      Pages: 2178-2181

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hepatitis C virus dealeses in patients with maintainance hemofiltration therapy2004

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Artificial Organs 28

      Pages: 316-318

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Therapeutic apheresis for ABO incompatible renal transplant2003

    • Author(s)
      石田英樹
    • Journal Title

      Therapeutic Apheresis 7(6)

      Pages: 520-528

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 腎移植における術後合併症とその対策2003

    • Author(s)
      石田英樹
    • Journal Title

      Medical Science Digest 29

      Pages: 18-21

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Therapeutic apheresis therapy for ABO-incompatible renal transplantiations2003

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Therapeutic Apheresis 7(6)

      Pages: 520-528

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Outcome of ABO incompatible renal transplantation without splenectomy2002

    • Author(s)
      Hideki ISHIDA, et al.
    • Journal Title

      Transplant Int 15(8)

      Pages: 56-58

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Anti-gal A/B, a novel antiblood group antibody identified in recipients of ABO-incompatible kidney allografts2002

    • Author(s)
      Galili Uri, Hideki Ishida et al.
    • Journal Title

      Transplantation 74(11)

      Pages: 1574-1580

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2006-07-11  

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