2004 Fiscal Year Final Research Report Summary
Analysis and identifying adhesion molecules on endometrial epithelial cells that induce and activate embryo
| Project/Area Number |
15591743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
KOSAKA Kenzo KYOTO UNIVERSITY, OB/GYN, Assistant Professor, 医学研究科, 助手 (90359828)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Shinya KYOTO UNIVERSITY, OB/GYN, Assistant Professor, 医学研究科, 助手 (90333575)
HIGUCHI Toshihiro KYOTO UNIVERSITY, OB/GYN, Assistant Professor, 医学研究科, 助手 (00283614)
FUJIWARA Hiroshi KYOTO UNIVERSITY, OB/GYN, Lecturer, 医学研究科, 講師 (30252456)
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| Project Period (FY) |
2003 – 2004
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| Keywords | endometrial epithelial cells / embryo / adhesion molecule / peripheral blood mononuclear cells / DNA array / Eph-ephrin |
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| Research Abstract |
This study demonstrated that ephrin A1 is expressed on human endometrial epithelial cells. On the other hand, mRNA expression of Eph A1 was detected in human embryos in the blastocyst stage, suggesting a physiological role of the Eph-ephrin system in embryo implantation. These findings indicate a possible interaction between human blastocysts and endometrial epithelial cells via the Eph-ephrin system. Because intracytoplasmic signals are induced by Eph receptors after ephrin stimulation, this system may be involved in the activation process of the human embryo during the implantation period.
Also, this study demonstrated that ALCAM is expressed on human endometrial epithelial cells and blastocysts. The developing stage-specific expression on the embryo suggests that the ALCAM-ALCAM cell adhesion system is involved in an initial interaction of the embryo with maternal endometrium.
Further investigation of these expression and functions of these molecules will provide new insights into the mechanisms of the initial embryo-maternal interaction.
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[Journal Article] Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.2004
Author(s)
Fujiwara H, Higuchi T, Yamada S, Hirano T, Sato Y, Nishioka Y, Yoshioka S, Tatsumi K, Ueda M, Maeda M, Fujii S.
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Journal Title
Biochem Biophys Res Commun. 23;313(4)
Pages: 962-968
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures.2003
Author(s)
Higuchi T, Fujiwara H, Egawa H, Sato Y, Yoshioka S, Tatsumi K, Itoh K, Maeda M, Fujita J, Fujii S.
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Journal Title
Mol Hum Reprod. 9(6)
Pages: 359-366
Description
「研究成果報告書概要(欧文)」より
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