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2017 Fiscal Year Final Research Report

Circadian clock oscillation in the SCN

Research Project

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Project/Area Number 15H01843
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic / Social brain science
Research InstitutionKyoto University

Principal Investigator

OKAMURA HITOSHI  京都大学, 薬学研究科, 教授 (60158813)

Co-Investigator(Renkei-kenkyūsha) YAMAGUCHI YOSHIAKI  京都大学, 薬学研究科, 助教 (30467427)
FUSTIN JEAN-MICHEL  京都大学, 薬学研究科, 特定講師 (50711818)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords概日リズム / 時計遺伝子 / シグナル伝達 / 視交叉上核 / Gタンパク質 / 細胞周期 / 時差 / 昼寝
Outline of Final Research Achievements

In Drosophila, it was elucidated that the transcription and translation feedback loop of the clock gene causes a circadian rhythm with a period of about 24 hours, and it won the 2017 Nobel Prize in Medicine and Physiology. We cloned mammalian Per gene in 1997, and clarified that the circadian oscillation was not generated simply clock genes by themselves, but needs intercellular neurotransmission among clock oscillating cells. In this research project, we identified GPR176-cAMP system as a key system to generate the rhythm, mathematical model of jet lag, alternative splicing of Ck1d gene for determining period length, mammalian calcitonin receptor in temperature regulation during nap, and role of Per for the formation of polyploidization.

Free Research Field

基盤・社会脳科学

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Published: 2019-03-29  

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