Analysis on the pathogenesis of inflammatory bowel diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02511
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Osaka University
• Principal Investigator: Takeda Kiyoshi 大阪大学, 医学系研究科, 教授 (20309446)
• Co-Investigator(Kenkyū-buntansha): 西村 潤一 大阪大学, 医学部附属病院, その他 (20379209)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Shota 大阪大学, 微生物病研究所, 特任准教授 (90432434)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 炎症性腸疾患

Outline of Final Research Achievements

We identified a novel subset of innate myeloid cells (CD160high CD163high cells) in the human intestinal lamina propria. This subset, which was present only in the intestine, produced high amounts of IL-10 and suppressed proliferation of effector T cells. In Crohn’s disease patients, suppressive function of effector T cell proliferation of the CD160high CD163high cell subset was impaired. In ulcerative colitis patients, the number of the subset was decreased and the suppressive function was also impaired. Thus, we showed that the unique subset of innate myeloid cells in the human intestinal lamina propria contributes to the maintenance of the intestinal homeostasis.

Free Research Field

免疫学