Development of functional food based on the improvement of mitochondrial dysfunction to prevent lifestyle related diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H02902
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits
• Research Institution: Tokai University
• Principal Investigator: Nagai Ryoji 東海大学, 農学部, 教授 (20315295)
• Co-Investigator(Kenkyū-buntansha): 松村 剛 熊本大学, 大学院生命科学研究部(医), 准教授 (20398192) ; 小野 政輝 東海大学, 農学部, 教授 (60177269) ; 坂田 則行 福岡大学, 医学部, 教授 (20134273)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミトコンドリア / 翻訳語修飾 / バイオマーカー

Outline of Final Research Achievements

We previously revealed that S-(2-succinyl) cysteine (2SC) accumulation in adipocyte is associated with mitochondrial dysfunction caused by hyperglycemia. In this study, analysis method of 2SC, which was considered to be difficult to measure, was further improved and it provides stable results with even 1uL of serum. It was demonstrated that some lifestyle related diseases such as diabetes are associated with 2SC accumulation in vivo and 2SC level in mice varies by organs. Furthermore, some extract from natural products shows inhibitory effects on 2SC formation. These results indicate that regular intake of effective compounds could help us to stay away from lifestyle related diseases such as diabetes complications.

Free Research Field

食品機能学・生化学