Effect of sex steroid hormones on aerobic exercise training-induced reduction of arterial stiffness

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: MESAKI Noboru 筑波大学, 体育系(名誉教授), 名誉教授 (30010408)
• Co-Investigator(Kenkyū-buntansha): 佐藤 幸治 神戸大学, 人間発達環境学研究科, 准教授 (20584022) ; 相澤 勝治 専修大学, 文学部, 准教授 (80375477) ; 家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 動脈硬化 / 性ステロイドホルモン

Outline of Final Research Achievements

This study was aimed to clarify whether the secretion of sex steroids hormones is associated with aerobic exercise training-induced reduction of arterial stiffness. To directly evidence exercise effect by using inhibitor of sex steroid hormone synthase, Male obese type 2 diabetic rats (OLETF) were randomly divided into 4 groups; sedentary obese control, 8-week aerobic training, aerobic training with continuous infusion of 5α-reductase inhibitor, or aerobic training with continuous infusion of P450 aromatase inhibitor groups. Aerobic exercise training in OLETF significantly reduced carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, as compared with the sedentary obese control group, whereas the training-induced reduction of cfPWV was not suppressed by administrations of the 5α-reductase and P450 aromatase inhibitors. These results suggest that sex steroids hormones may be not associated with aerobic exercise training-induced reduction of arterial stiffness.

Free Research Field

スポーツ医学