Development of exercise and diet prescription considering the genetic risk score of sarcopenia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Ritsumeikan University
• Principal Investigator: Sanada Kiyoshi 立命館大学, スポーツ健康科学部, 教授 (50421227)
• Co-Investigator(Kenkyū-buntansha): 村上 晴香 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 室長 (20344880) ; 宮地 元彦 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 部長 (60229870) ; 家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: サルコペニア / 医療・福祉 / 運動 / 食事 / 遺伝子

Outline of Final Research Achievements

In this study, we performed genome-wide association analyses (GWAS) of CNV for sarcopenia in 506 Japanese subjects. Appendicular muscle mass (AMM) was measured by dual-energy X-ray absorptiometry. Reference values for classes 2 sarcopenia (skeletal muscle index ; AMM/height2, kg/m2) in each sex were defined as values two standard deviations below the sex-specific means of reference values obtained in our cohort database from young adults aged 18-40 years（Sanada et al Eur J Appl Physiol, 2010）. The reference values for class 2 sarcopenia were 6.87 kg/m2 in men and 5.46 kg/m2 in women. We analyzed 6 million SNPs using HumanOmni-Quad BeadChip (Illumina co., ltd). Consequently, 49SNPs were detected to be associated with sarcopenia (p<1.00×10-5). This study predicts regulatory networks of ESR1 and MEGF10 in sarcopenia using bioinformatics analysis. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in Japanese sarcopenia.

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