Exploring new drug targets based on binding protein identification of bioactive natural products

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03114
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomolecular chemistry
• Research Institution: Osaka University
• Principal Investigator: ARAI Masayoshi 大阪大学, 薬学研究科, 特任教授(常勤) (80311231)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Motomasa 大阪大学, 大学院・薬学研究科, 招へい教授 (40116033) ; KOTOKU Naoyuki 立命館大学, 薬学部, 准教授 (20362618)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 活性天然物 / 標的分子 / ケミカルバイオロジー / 感染症 / がん

Outline of Final Research Achievements

In this study, we conducted an exploratory study of bioactive natural products effective for cancer and tuberculosis using established screening systems focusing on unique phenotypic changes of cells and pathogenic microbes in tumor and infected region. As a result, 14 bioactive natural products containing 7 novel compounds were discovered. In addition, we analyzed the action mechanism and binding protein of isolated bioactive natural products using the methods of molecular biology or chemical biology. Then, several molecules that were expected to be new drug targets, were successfully identified.

Free Research Field

天然物化学　ケミカルバイオロジー