Research on fish scale collagen material technology by field fusion

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03526
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanomaterials chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Ikoma Toshiyuki 東京工業大学, 物質理工学院, 准教授 (20370306)
• Co-Investigator(Kenkyū-buntansha): 田中 利明 東京工業大学, 生命理工学院, 助教 (40263446) ; 杉山 友明 東京工業大学, 物質理工学院, 助教 (90744178)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生体外マトリックス / 細胞分泌 / コラーゲン

Outline of Final Research Achievements

In order to clarify the aligned collagen fibrils and sugar modification of collagen as well as the formation factors of oriented extracellular matrix of collagen fibrils, gradient materials of collagen and hydroxyapatite by electrochemical reaction and the glycosylated collagen using thiolate reaction were succeeded. It was revealed that glycosylation increased the initial adhesion number of fibroblasts. We also established a technique to visualize collagen secretion from cells and clarified that in situ collagen integrity process and in situ measurement of secretion status. By utilizing these technologies, it can be expected to be useful for future scaffolds for regenerative medicine and devices for drug discovery development.

Free Research Field

生体材料