Synthesis of boron-containing organic materials by novel nucleophilic borylation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03804
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Ito Hajime 北海道大学, 工学研究院, 教授 (90282300)
• Co-Investigator(Kenkyū-buntansha): 石山 竜生 北海道大学, 工学研究院, 准教授 (00232348) ; 関 朋宏 北海道大学, 工学研究院, 助教 (50638187)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 銅(I)触媒 / 塩基触媒 / 有機ホウ素化合物 / 不斉合成

Outline of Final Research Achievements

In this research, by using copper-catalyzed reactions and base-mediated reactions, we developed many useful synthetic reactions of organoboron compounds: alkyl-, alkenyl-, aryl, alkynyl halides, ketones, aldehydes, indole, pyridine, quinoline derivatives were applied to the boryl substitution reaction, boryl addition reaction, boryl cyclization reactions, dearomative borylations. We also develop asymmetric catalytic borylation through applying chiral catalysts to some of these new reactions. This research project afforded a significant amount of results of the development of many synthetic reactions of organoboron compounds, which are useful reagents on organic synthesis.

Free Research Field

有機合成化学