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2018 Fiscal Year Final Research Report

Improvement of an animal cell-displaying technology by using a splicing factor

Research Project

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Project/Area Number 15H04196
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biofunction/Bioprocess
Research InstitutionOkayama University

Principal Investigator

Kanayama Naoki  岡山大学, ヘルスシステム統合科学研究科, 准教授 (70304334)

Co-Investigator(Kenkyū-buntansha) 徳光 浩  岡山大学, ヘルスシステム統合科学研究科, 教授 (20237077)
曲 正樹  岡山大学, ヘルスシステム統合科学研究科, 助教 (50359882)
Project Period (FY) 2015-04-01 – 2019-03-31
Keywords抗体
Outline of Final Research Achievements

We have been developing an animal cell-displaying technology using the hypermutating B cell line DT40. In this study, we elucidated a function of a splicing factor, SRSF1, which we have previously found that is essential for hypermutation of the immunoglobulin gene, and developed a method to increase hypermutation efficiency by manipulation of SRSF1 expression.

Free Research Field

細胞工学、抗体工学

Academic Significance and Societal Importance of the Research Achievements

標的に特異的に結合する抗体は、抗体医薬と呼ばれる副作用の低い次世代の分子標的治療薬として活用されてきている。抗体医薬開発での問題の一つに抗体ライブラリーの多様性の不足が考えられ、本研究は有用な活性を有する変異抗体を含む質の高い抗体ライブラリーの効率的作製に寄与しうる。

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Published: 2020-03-30  

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