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2017 Fiscal Year Final Research Report

Establishment of heredital desease models using iPS cells and genome editing

Research Project

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Project/Area Number 15H04286
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKyoto University (2017)
University of Miyazaki (2015-2016)

Principal Investigator

Honda Arata  京都大学, 京都市, 特定准教授 (10373367)

Co-Investigator(Kenkyū-buntansha) 下島 圭子  東京女子医科大学, 医学部, 特任助教 (30578935)
山海 直  国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 霊長類医科学研究センター, 主任研究員 (80300937)
Co-Investigator(Renkei-kenkyūsha) OGURA Atsuo  独立行政法人理化学研究所, バイオリソース研究センター, 室長 (20194524)
MATSUDA Osamu  京都府立医科大学, 医学系研究科, 教授 (00271164)
Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsExperimental Animals / ES cells / iPS cells / naive / germ cells / chimera
Outline of Final Research Achievements

This research project had been aimed for the establishment of heredital desease models using iPS cells and genome editing using several animal species. We achieved naive-like conversion of cynomolgus monkey ES/iPS cells, which can enhances their in vitro differentiation potential. Moreover, following mice and rats, the 3rd true naive-iPS cells were successfully established form an endangered species, Tokudaia osimensis. We produced interspecific chimera and elucidated the sexual plasticity of the germ cells of the endangered species.

Free Research Field

Experimental Animals

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Published: 2019-03-29  

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