Study on the mechanisms of tumor progression induced by dysregulation of Src oncoprotein

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04296
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Osaka University
• Principal Investigator: Okada Masato 大阪大学, 微生物病研究所, 教授 (10177058)
• Co-Investigator(Kenkyū-buntansha): 小根山 千歳 愛知県がんセンター(研究所), 感染腫瘍学部, 部長 (90373208)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん進展 / 浸潤転移 / Src / チロシンキナーゼ

Outline of Final Research Achievements

Src tyrosine kinase is the first-identified onco-protein, and plays a crucial role in promoting tumor malignancy, such as invasive and metastatic ability, when its function is upregulated during tumor progression. However, molecular mechanism underlying the dysregulation of Src expression/activity and its actual roles in tumor progression remain elusive. To address these issues, we analyzed the regulatory mechanism of SRC gene expression and the functions of scaffold proteins that activate Src. Based on these analyses, we proposed new models of the molecular mechanisms for Src-mediated tumor progression.

Free Research Field

生化学・腫瘍生物学