2017 Fiscal Year Final Research Report
Regulation of vesicular trafficking by tethering complex and SNARE proteins
| Project/Area Number |
15H04370
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KATOH Yohei 京都大学, 大学院薬学研究科, 助教 (90568172)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 小胞輸送 / SNAREタンパク質 / Exocyst複合体 / IFT-B複合体 |
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| Outline of Final Research Achievements |
Membrane fusion, which is the last step of vesicular trafficking, is mediated by SNARE proteins. In this study, we have revealed that fusion of recycling vesicles containing transferrin-transferrin receptor is regulated by t-SNARE proteins, SNAP-23/SNAP-25 in conjunction with the Exocyst tethering complex.
By taking advantage of the visible immunoprecipitation (VIP) assay, we have revealed the architectures of various protein complex, including the Exocyst complex, involved in protein trafficking within cells.
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| Free Research Field |
分子細胞生物学
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