Study for elucidation of the structures and functions of nano-sized membrane domains using glycolipid probes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04495
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioorganic chemistry
• Research Institution: Gifu University
• Principal Investigator: ANDO Hiromune 岐阜大学, 研究推進・社会連携機構, 教授 (20372518)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Kenichi 岐阜大学, 研究推進・社会連携機構, 教授 (50423059)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞膜ドメイン / 脂質ラフト / ガングリオシド / 1分子イメージング

Outline of Final Research Achievements

Research aim: To figure out the mechansims of the formation of the tentatively formed cell membrane domains by the single molecule imaging tequnique. This research mainly focuses on the behavior of glycolipids, which are key components of the cell membrane domains.

Research outcomes: A series of the fluorescent labeled glycolipids which are useful as equivalents to native molecules has been developed for the first time. We have found the molecular interactions fundamental and essential for the formations of lipid raft and glycolipid domain by the single molecule imaging technique.

Free Research Field

糖鎖合成化学、生物有機化学