2017 Fiscal Year Final Research Report
Effects of simultaneous deficiency of vitamins C and E on memory, learning behavior, lipid metabolism, aging and age-associated disease
| Project/Area Number |
15H04505
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Ishigami Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 老化 / 食品 |
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| Outline of Final Research Achievements |
We established SMP30/αTTP double knockout mice as a novel double-deficient model for both vitamin C and vitamin E. SMP30/αTTP double knockout mice showed impaired cue and context-dependent fear memory if both vitamin C and vitamin E were deficient. Moreover, simultaneous deficiency of vitamin C and E revealed that it affects lipid metabolism in the liver.
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| Free Research Field |
老化
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