The role of canine AIM in histiocytic sarcoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04590
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: The University of Tokyo
• Principal Investigator: Yonezawa Tomohiro 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)
• Co-Investigator(Kenkyū-buntansha): 松木 直章 東京大学, 大学院農学生命科学研究科(農学部), 教授 (40251417) ; 盆子原 誠 日本獣医生命科学大学, 獣医学部, 教授 (50343611)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マクロファージ / 組織球性肉腫 / 犬

Outline of Final Research Achievements

Histiocytic sarcoma, macrophage-derived tumor is seriously malignant and therapeutic method is not established. In this study, we focused on apoptosis inhibitor of macrophage (AIM). It is found that AIM is expressed in several normal tissues and histiocytic tumors. When AIM expression vector was transfected into histiocytic cell lines, the cell number was reduced. Canine recombinant AIM also could induce apoptosis of these cells. It is suggested canine AIM has apoptotic inducing effect in histiocytic sarcoma.

Free Research Field

獣医学