2017 Fiscal Year Final Research Report
Action mechanism of pH-sensing OGR1 family receptors and in vivo functions
| Project/Area Number |
15H04641
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Aomori University (2016-2017)
Gunma University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 幸市 群馬大学, 生体調節研究所, 准教授 (00302498)
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| Research Collaborator |
MOGI Chihiro
AOKI Haruka
HISADA Takeshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | プロトン / TDAG8 / OGR1 / GPR4 / ミクログリア / 骨代謝 / 内皮細胞 / 樹状細胞 |
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| Outline of Final Research Achievements |
It is well known that acidification takes place in the ischemia and inflammatory region. However, how extracellular acidic pH regulates physiological and pathophysiological actions remains uncharacterized yet. In the present study, we investigated the roles of OGR1 family GPCRs, including OGR1, TDAG8, and GPR4, which have been recently identified as extracellular proton-sensing receptors, in bone remodeling, brain ischemia, tumorigenesis, and asthma. The results showed that these receptors play important roles in the physiological cellular functions and the development of ischemic and inflammatory disorders. We further characterized a novel GPR4 antagonist and found that it was effective in the myocardial infarction model.
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| Free Research Field |
生理化学
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