2017 Fiscal Year Final Research Report
Nuclear redox regulation and its roles in pathological basis of aging-related diseases
| Project/Area Number |
15H04692
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 内因性親電子性物質 / ホルムアルデヒド / DNA損傷 / 酸化ストレス |
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| Outline of Final Research Achievements |
It has been recognized that various active redox reactions take place in the nucleus together with epigenetic regulation and DNA recombination and repair. However, regulatory mechanisms of these intranuclear redox reactions as well as pathological conditions caused by their defects have not been well understood. In this study, we aimed at clarifying effects of endogenous electrophiles on genome and epigenome. Functional relations between ADH5, which is a detoxification enzyme of formaldehyde, and FANCD2, which is one of the DNA repair factors, were examined. And redox-sensitive regulatory mechanisms of ADH5 enzymatic activity were also examined.
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| Free Research Field |
生化学・分子生物学
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