Regulation of the heat shock response by mitochondrial signals

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04706
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Yamaguchi University
• Principal Investigator: NAKAI Akira 山口大学, 大学院医学系研究科, 教授 (60252516)
• Co-Investigator(Kenkyū-buntansha): 藤本 充章 山口大学, 大学院医学系研究科, 准教授 (80359900) ; 瀧井 良祐 山口大学, 大学院医学系研究科, 助教 (00419558)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: protein homeostasis / heat shock / chaperone / transcription / mitochondria / HSF1 / SSBP1

Outline of Final Research Achievements

In response to proteotoxic stresses including heat shock, cells maintain protein homeostasis through an adaptive response called the heat shock response. This response is regulated at a level of transcription by heat shock transcription factor 1 (HSF1). We here show that HSF1 interacts with SSBP1, which is involved in replication and metabolism of mitochondrial DNA. Furthermore, HSF1-SSBP1 accumulates in the nucleus and maintains mitochondrial function during proteotoxic stress.

Free Research Field

医化学