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2017 Fiscal Year Final Research Report

Identification and clinical application of diagnostic and therapeutic marker of esophageal and gastric cancer targeting cancer stem cell

Research Project

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Project/Area Number 15H04713
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionHiroshima University

Principal Investigator

YASUI WATARU  広島大学, 医歯薬保健学研究科(医), 教授 (40191118)

Co-Investigator(Renkei-kenkyūsha) OUE NAOHIDE  広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484)
KUNIYASU HIROKI  奈良県立医科大学, 医学部, 教授 (00253055)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords食道癌 / 胃癌 / 癌幹細胞 / CAST法 / 新規診断・治療標的
Outline of Final Research Achievements

As candidate diagnostic and therapeutic targets of esophageal and gastric cancers associated with spheroid-forming cancer stem cells, kinesin family (KIFC1, KIF11, KIF23), IQGAP3, DSG1 were identified. BST2 and MCOLN3, identified from 5-FU-resistant gastric cancer cells, were found to regulate chemosensitivity. These findings will contribute to the application to the diagnosis and treatment for therapy-resistant cancer stem cells.

Free Research Field

医歯薬学

URL: 

Published: 2019-03-29  

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