2017 Fiscal Year Final Research Report
Immunological aspects of cancer stem cell and spermatogenesis
| Project/Area Number |
15H04722
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | がん幹細胞 / 免疫療法 / 班精巣抗原 |
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| Outline of Final Research Achievements |
In this research project, we isolated highly tumorigenic cancer stem cells from human colon cancer, cervical cancer and lung cancer cells. We examined the expression profiles of cancer stem cells by cDNA microarry, and we found that numbers of testis-related genes are expressed in cancer stem cells. Those are OR7C1, BORIS SMCP and DNAJB8. Importantly, gene specific knockdown using siRNAs revealed that testis-related genes have important role in the maintenance of cancer stem cells. And we also identified testis-related gene products can be targeted by immunotherapy. These results indicate that immunotherapy targeting testis-related gene products is a promising approach to target cancer stem cells.
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| Free Research Field |
実験病理
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