2017 Fiscal Year Final Research Report
Mechanism for the formation of cheating organella of Toxoplasma gondii
| Project/Area Number |
15H04726
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
案浦 健 国立感染症研究所, 寄生動物部, 主任研究官 (90407239)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 原虫 / オルガネラ / リクルート |
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| Outline of Final Research Achievements |
It is known that Toxoplasma gondii can recruit the host mitochondria to its parasitophorous vacuole. First of this study, I identified 7 candidates responsible for this phenomenon, and evaluate the ability for the recruitment using with overexpressors. As a result, I could identify four genes responsible for the mitochondrial recruitment of T. gondii. I further tried to knock-out these genes. However, I could not knock-out three of them because they might be essential. I established knock-out mutant of remaining gene. This mutant decreased the recruitment ability of the host mitochondria.
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| Free Research Field |
分子寄生虫学、原生生物学
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