Development of the personalized prevention system by longitudinal exome-wide association studies of common complex diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04772
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Mie University
• Principal Investigator: YAMADA Yoshiji 三重大学, 地域イノベーション推進機構, 教授 (90333286)
• Co-Investigator(Renkei-kenkyūsha): Takeuchi Ichiro 名古屋工業大学, 大学院工学研究科, 教授 (40335146)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エクソーム全領域関連解析 / 冠動脈疾患 / 脂質異常症 / 糖尿病 / 慢性腎臓病 / 高尿酸血症 / 肥満 / メタボリックシンドローム

Outline of Final Research Achievements

We developped database for 6048 community-dwelling individuals containing 242,901 single nucleotide polymorphisms and temporal epidemiological data. We then performed exome-wide association studies by the use of these data and identified various genes and polymorphisms that confer susceptibility to hypertension, type 2 diabetes mellitus, dyslipidemia, chronic kidney disease, obesity, metabolic syndrome, hyperuricemia, coronary artery disease, or ischemic stroke. Base on the results of the present study, we will contribute to personalized prevention of hypertension, type 2 diabetes mellitus, hypertriglyceridemia, hypo-HDL-cholesterolemia, hyper-LDL-cholesterolemia, chronic kidney disease, obesity, metabolic syndrome, hyperuricemia, coronary artery disease, and ischemic stroke in Japanese individuals.

Free Research Field

ゲノム疫学