2017 Fiscal Year Final Research Report
Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
| Project/Area Number |
15H04820
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
朝野 仁裕 大阪大学, 医学系研究科, 講師 (60527670)
塚本 蔵 大阪大学, 医学系研究科, 助教 (80589151)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 心不全 / ナトリウム利尿ホルモン / エンハンサー / シグナル伝達 / 創薬 |
|---|
| Outline of Final Research Achievements |
We clarified how natriuretic peptides ANP and BNP, which are elevated and become severity markers during heart failure and are also used as therapeutic agents, are regulated in vivo. The results of this project are as follows.(1) Expression of heart failure in ANP and BNP is regulated by about 600 bp enhancer positioned about 20 kb upstream of the gene, and is induced by binding of factors.(2) Even in catecholamine stimulation, this expression signal is not transmitted when the movement of the heart is stopped, and this signal is transmitted by the two types of mechanostress, so that mechanical stimulation is involved in this signal induction even at the cellular level.
It is clarified how signal transduction in heart failure is transmitted, and it is expected to lead to the development of drugs for the treatment of heart failure targeting these signals.
|
| Free Research Field |
医化学
|
