Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04842
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Juntendo University
• Principal Investigator: Hattori Nobutaka 順天堂大学, 医学(系)研究科(研究院), 教授 (80218510)
• Co-Investigator(Kenkyū-buntansha): 佐藤 栄人 順天堂大学, 医学部, 准教授 (00445537)
• Co-Investigator(Renkei-kenkyūsha): IMAI Yuzuru 順天堂大学, 医学部, 准教授 (30321730) ; FUNAYAMA Manabu 順天堂大学, 医学部, 准教授 (70468578) ; HATANO Taku 順天堂大学, 医学部, 准教授 (60338390)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: パーキンソン病 / ミトコンドリア / リソソーム / ATP13A2 / CHCHD2

Outline of Final Research Achievements

We have generated model animals with hereditary Parkinson's disease (PD) causative genes to clarify the mechanism of Lewy body formation and common PD pathology. ATP13A2 and GBA mutations cause of PD and induce lysosomal defects and aberrant homeostasis. As the results, the change of lipid composition, which may affect synuclein metabolism and degradation was one of the important factor of Lewy body formation and PD pathology.

Free Research Field

神経学