Analysis of target antigens and pathogenetic mechanisms of neuroimmunological diseases using glycoarray

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04845
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kindai University
• Principal Investigator: KUSUNOKI Susumu 近畿大学, 医学部, 教授 (90195438)
• Co-Investigator(Kenkyū-buntansha): 桑原 基 近畿大学, 医学部, 講師 (40460860) ; 西郷 和真 近畿大学, 理工学部, 准教授 (50319688) ; 宮本 勝一 近畿大学, 医学部, 准教授 (50388526)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 免疫性神経疾患 / 自己抗体 / 糖脂質 / ガングリオシド / 末梢神経障害

Outline of Final Research Achievements

Serum antibodies to glycolipids and glycolipid complexes in patients with neuroimmunological diseases were investigated comprehensively using glycoarray. Antibody activities to glycolipid complexes containing sulfatide in Guillain-Barré syndrome (GBS) and to those containing GalNAc-GD1a in multifocal motor neuropathy (MMN) were newly found by the present study. It was suggested that those antibodies are involved in the pathogenetic mechanisms of GBS and MMN. Among the patients with anti-GQ1b antibody-associated diseases, antibodies to glycolipid complexes containing GD1b were frequently present in GBS. Patients with such antibodies were frequently affected with severe GBS. Clinical features of neuroimmunological diseases with anti-Gal-C antibodies and those of neuropathy with anti-neurofascin 155 antibodies were revealed.

Free Research Field

神経内科学