Peripheral Circadian Dysregulation and Metabolic Disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04849
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Yamaguchi University
• Principal Investigator: TANIZAWA Yukio 山口大学, 大学院医学系研究科, 教授 (00217142)
• Co-Investigator(Kenkyū-buntansha): 太田 康晴 山口大学, 医学部, 准教授(寄附講座等) (60448280) ; 田部 勝也 山口大学, 医学部附属病院, 講師 (00397994) ; 幡中 雅行 山口大学, 医学(系)研究科(研究院), 助教 (60572534) ; 秋山 優 山口大学, 医学部附属病院, 助教 (90717547)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 体内時計 / 糖尿病 / 糖代謝 / インスリン分泌 / E4BP4 / DBP / サーカディアンリズム

Outline of Final Research Achievements

We all have biological clock inside the body. Biological clock is composed of clock genes, which have feedback loop of expression regulation, and make 24-hours circadian expression rhythm. Clocks regulate many biological processes including metabolism. Dysregulation of the biological clock causes many disease processes including metabolic disorders, such as diabetes mellitus. We found that DBP and E4BP4, which are reciprocally expressed and regulate the same set of target genes, play crucial role among clock genes. Abnormalities in this system cause severe insulin secretory defects and diabetes in a mouse model. In addition, those genes appear to be important in the regulation of liver metabolism.

Free Research Field

内分泌代謝学